{"product_id":"abcam-ab185968","title":"Abcam, ab185968, Anti-FGD2 antibody [EPR15306] - N-terminal","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal FGD2 antibody. N-terminal. Suitable for WB, ICC\/IF, IHC-P and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR15306,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nFGD2 also known as FYVE RhoGEF and PH domain-containing protein 6 (FGD1) is a protein with a mass of about 92 kDa. FGD2 functions mechanically as a guanine nucleotide exchange factor (GEF) that activates Rho GTPases. This protein is mostly expressed in hematopoietic tissues including the spleen and lymph nodes. FGD2 facilitates actin cytoskeleton organization which is essential for various cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFGD2 has a role in cellular signaling and cytoskeletal dynamics. It regulates the activation of Rho GTPases such as Cdc42 a small signaling G protein. FGD2 does not function within a known protein complex but partners with other signaling molecules to influence cell shape and movement. This biological activity affects how cells respond to external stimuli.\u003cbr\u003e\nPathways\u003cbr\u003e\nFGD2 is involved in regulating cytoskeleton organization and cell signaling pathways. In the context of the Wnt signaling pathway FGD2 interacts with proteins that modulate cytoskeletal rearrangement such as Rac1 and Cdc42. These interactions suggest FGD2 influences pathways critical for cell division and differentiation.\u003cbr\u003e\nAbnormalities in FGD2 are related to immune system disorders and some cancers. Dysregulated FGD2 expression associates especially with Hodgkin's lymphoma where it affects actin polymerization and cell migration. Additionally alterations in FGD2 interact with beta-catenin in Wnt signaling pathways related to tumorigenesis. Understanding FGD2's role can provide insights into therapeutic strategies for disorders linked to actin cytoskeletal defects.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850369683625,"sku":"ab185968","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab185968","provider":"Iright","version":"1.0","type":"link"}