{"product_id":"abcam-ab186408","title":"Abcam, ab186408, Anti-ADH7 antibody [EPR13949]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal ADH7 antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR13949,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe biological target ADH7 also known as alcohol dehydrogenase 7 or class IV ADH is an enzyme with a molecular mass of approximately 38 kDa. ADH7 belongs to the alcohol dehydrogenase family and participates in the oxidative reduction of alcohols to aldehydes or ketones. This enzyme is expressed mainly in the stomach and to a lesser extent in the liver and other tissues. The expression levels depend on genetic variation among different populations.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nADH7 plays a role in metabolizing retinoids and ethanol in the body. It does not form a complex but acts as a monomer in enzymatic reactions. By converting alcohols to their aldehyde forms ADH7 participates in detoxification processes and helps maintain homeostasis of retinoid metabolites. This function involves the interaction of ADH7 with other alcohol dehydrogenases that process overlapping substrate types.\u003cbr\u003e\nPathways\u003cbr\u003e\nADH7 is involved in the retinol metabolism pathway and ethanol degradation pathway. In the retinol metabolism pathway it works alongside other enzymes such as retinol dehydrogenase to maintain vitamin A homeostasis. These pathways are important for detoxifying alcohols and maintaining cell signaling processes. Through some metabolic connections ADH7 interacts with proteins like CYP2E1 in ethanol degradation highlighting a collaborative yet distinct pathway environment.\u003cbr\u003e\nADH7 shows a connection to alcoholism and gastric cancer. Genetic variations in ADH7 may influence individual susceptibility to alcohol dependence due to altered alcohol metabolism. Additionally owing to its presence in gastric tissues ADH7's interaction with aldehyde dehydrogenase can modulate the development of gastric cancer under certain conditions emphasizing its relevance in disease etiology and potential therapeutic exploration.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844195438761,"sku":"ab186408","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab186408","provider":"Iright","version":"1.0","type":"link"}