{"product_id":"abcam-ab18684","title":"Abcam, ab18684, Anti-Hepatitis B Virus Core Antigen antibody [13A9]","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nMouse Monoclonal Hepatitis B Virus Core Antigen antibody. Suitable for IP, ELISA, WB and reacts with Hepatitis B virus samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:13A9,\u003cbr\u003e\nIsotype:IgG2b,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Hepatitis B virus,\u003cbr\u003e\nApplications:ELISA, IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nEpitope:Peptide maps to amino acids 135 to 140 of the core antigen.,\u003cbr\u003e\nSpecificity:Hepatitis B Virus Core Antigen (ayw)\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.6Preservative: 0.01% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Hepatitis B Virus Core Antigen also known as HBV core antigen or Hep B core is an important component of the hepatitis B virus (HBV). This antigen often referred to simply as 'core' forms the nucleocapsid of the virus. The HBV core antigen consists of a protein structure with a mass of approximately 21 kilodaltons. It is primarily expressed within the hepatocytes the liver cells where it plays a pivotal role in viral replication and assembly. The HBV core antigen is also referred to in studies as HBV protein or B core.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe hepatitis B core antigen is integral for the assembly of the viral capsid which protects the viral genome during infection. It functions as part of a larger complex with other viral proteins including the pre-core and envelope proteins to facilitate viral lifecycle processes. This antigen allows for the encapsidation of viral RNA and serves as a scaffold for reverse transcription of the viral genome ensuring replication fidelity and successful infection spread.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe hepatitis B core antigen is essential in the viral replication pathway and the HBV lifecycle pathway. It interacts closely with HBV polymerase during the packaging of viral genome into the capsid. These interactions are important for the transformation of RNA into DNA a critical step in viral maturation. The antigen is related to the HBx protein through these pathways; the HBx protein modulates viral replication and can influence the pathogenesis of the virus.\u003cbr\u003e\nThe hepatitis B core antigen is strongly linked to chronic hepatitis B infection and liver diseases such as cirrhosis and hepatocellular carcinoma. The persistence of the core antigen in infected hepatocytes signifies ongoing viral replication which can lead to liver inflammation and damage. The interaction of the core antigen with immune system components such as anti-HBc antibodies assists in the diagnosis and monitoring of disease progression. It connects to the envelope proteins during the disease process which are important in immune system evasion and chronic infection establishment.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855436992681,"sku":"ab18684","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab18684","provider":"Iright","version":"1.0","type":"link"}