{"product_id":"abcam-ab187679","title":"Abcam, ab187679, Anti-Rag D antibody - N-terminal","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal Rag D antibody. N-terminal. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human RRAGD aa 1-50.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human RRAGD aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q9NQL2\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate\/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRag D also known by its alternate names RAGA or GTRAG4 is a 40 kDa protein that serves as a regulator of intracellular nutrient signaling. Rag D is expressed in various cell types across numerous tissues. Mechanically it functions as a GTPase cycling between inactive GDP-bound and active GTP-bound states. This cycling is essential for its role in cellular metabolism and growth regulation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRag D participates in the mTORC1 complex a protein complex that senses nutrient availability. It acts as a molecular switch signaling cells to grow or stop growth based on amino acid presence. Rag D facilitates mTORC1 activation by recruiting it to the lysosomal surface where amino acids act as a trigger. This function allows Rag D to play a significant role in cell growth division and metabolism.\u003cbr\u003e\nPathways\u003cbr\u003e\nRag D integrates into the amino acid sensing pathway directly affecting the mTOR signaling pathway important for cellular growth and homeostasis. Rag D interacts with other Rag proteins such as Rag A and Rag C to form heterodimers that regulate mTORC1 activity. This interaction ensures Rag D can sense and respond to intracellular nutrient levels contributing to homeostatic balance.\u003cbr\u003e\nAbnormal Rag D function relates to cancer and metabolic conditions like diabetes. Dysregulated mTORC1 signaling where Rag D is an important component has been implicated in tumorigenesis and insulin resistance. Rag D interactions with proteins like TSC2 which modulate mTORC1 activity highlight its relevance in disease states where nutrient sensing is disrupted.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860700319913,"sku":"ab187679","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab187679","provider":"Iright","version":"1.0","type":"link"}