{"product_id":"abcam-ab188583","title":"Abcam, ab188583, Anti-Syntaxin antibody [EPR15139(B)]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal Syntaxin antibody. Suitable for IP, WB, IHC-P, ICC\/IF and reacts with Human, Mouse, Rat samples. Cited in 6 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR15139(B),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IHC-P, WB, ICC\/IF, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSyntaxin also known as HPC-1 or STX1A functions as an important component in the vesicle docking and fusion process particularly in neuronal exocytosis. This protein weighs approximately 33 kDa and has a significant presence in the brain especially in the synapses. Syntaxin belongs to the SNARE protein family and plays a pivotal role in facilitating the fusion of synaptic vesicles with the presynaptic membrane allowing neurotransmitter release. Its expression is not limited to nervous tissue but occurs in various other tissues reflecting its versatile roles in cellular activities.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSyntaxin interacts with other SNARE proteins such as SNAP-25 and VAMP to form the SNARE complex essential for synaptic vesicle fusion and neurotransmitter release. This complex mediates the membrane fusion process vital for effective neuronal communication. Syntaxin exhibits interaction with several regulatory proteins like Munc18 which stabilizes its closed conformation critical in maintaining a reservoir of readily releasable vesicles. Its involvement in the SNARE complex marks its importance in cellular exocytosis and endocytosis.\u003cbr\u003e\nPathways\u003cbr\u003e\nSyntaxin participates prominently in the neurotransmission and secretion pathways. It interacts within the neurotransmission pathway by associating with SNAP-25 and VAMP facilitating rapid neurotransmitter release in synaptic transmission. Additionally in the secretion pathway Syntaxin involvement extends to insulin release interacting with proteins like Munc18 and enhancing vesicular transport processes. Its action in these pathways demonstrates its fundamental role in cellular signaling and material transport.\u003cbr\u003e\nSyntaxin's dysfunction has links to neurological conditions such as Alzheimer's disease and botulism. In Alzheimer's disease abnormal Syntaxin interaction may impair synaptic function and neurotransmitter release leading to cognitive deficits. Botulism caused by botulinum toxin disrupts Syntaxin-mediated vesicle docking leading to muscular paralysis. Related proteins like SNAP-25 also play a role in these conditions emphasizing the complex network within the SNARE pathway that Syntaxin operates within highlighting its significance in maintaining cellular homeostasis and function.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855851868329,"sku":"ab188583","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab188583","provider":"Iright","version":"1.0","type":"link"}