{"product_id":"abcam-ab189519","title":"Abcam, ab189519, Anti-AFG2 antibody [EPR14038]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal AFG2 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 3 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR14038,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAFG2 also known as ATP-dependent metalloprotease FtsH2 is an essential protein involved in protein quality control within mitochondria. This protein acts mechanically as a protease enabling the degradation of misfolded or damaged proteins preventing accumulation within the mitochondrial matrix. AFG2 has a molecular mass of approximately 80 kDa. It is expressed across various tissues predominantly in those with high-energy demands such as cardiac and skeletal muscles.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFtsH2 forms part of the m-AAA protease complex. This complex consists of other subunits that work together to maintain mitochondrial function. AFG2 contributes to mitochondrial protein homeostasis by degrading unassembled or faulty proteins. It also plays a significant role in the processing of mitochondrial ribosomal proteins ensuring efficient ribosome function and mitochondrial protein synthesis.\u003cbr\u003e\nPathways\u003cbr\u003e\nAFG2 contributes significantly to mitochondrial biogenesis and the oxidative phosphorylation system. It interacts with other proteins such as paraplegin to regulate mitochondrial function and network maintenance. AFG2 ensures proteostasis within the mitochondria directly impacting cellular energy production. Its involvement in pathways ensures the balance of mitochondrial dynamics influencing cellular metabolism and energy distribution.\u003cbr\u003e\nAlterations in AFG2 activity often associate with neurodegenerative diseases such as hereditary spastic paraplegia and spinocerebellar ataxia. Mutations or dysregulation of AFG2 can disrupt mitochondrial proteostasis and function leading to these conditions. Additionally the protein is linked to paraplegin whose mutations may result in similar mitochondrial dysfunction emphasizing the interconnectedness of mitochondrial proteases in maintaining neurological health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850445770921,"sku":"ab189519","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab189519","provider":"Iright","version":"1.0","type":"link"}