{"product_id":"abcam-ab189823","title":"Abcam, ab189823, Anti-Apelin antibody [EPNCIR154] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal Apelin antibody. Carrier free. Suitable for ELISA and reacts with Synthetic peptide, Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPNCIR154,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab189823 is the carrier-free version of\u003cbr\u003e\nab133624\u003cbr\u003e\nThis antibody was developed as part of a collaboration between Epitomics, the National Cancer Institute's Center for Cancer Research and the lab of David Solomon.\u003cbr\u003e\nView antibodies from NCI Center for Cancer Research Collaboration\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nApelin also known as APLN is a peptide ligand with a mass of approximately 77 amino acids. It has gained attention in scientific research due to its interaction with the G-protein coupled receptor named APJ (Apelin receptor). Apelin expresses widely in various tissues including heart lung kidney and gastrointestinal tract. This widespread expression suggests it plays roles in multiple physiological processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nApelin acts as an important regulator of cardiovascular functions and fluid homeostasis. It modulates blood pressure and cardiac contractility indicating its role in maintaining cardiovascular health. Apelin operates independently but interacts closely with its receptor APJ forming a functional complex that initiates various intracellular signaling mechanisms. Researchers have noted its significant effects on the vascular system and potential involvement in angiogenesis.\u003cbr\u003e\nPathways\u003cbr\u003e\nApelin participates in the renin-angiotensin system and influences the nitric oxide signaling pathway. These pathways are important for maintaining vascular tone and pressure as well as for ensuring proper fluid balance in the body. Apelin's actions appear related to the angiotensin II type 1 receptor and endothelial nitric oxide synthase affecting their activity to achieve desired physiological outcomes. This involvement illustrates how apelin bridges different signaling networks to regulate homeostasis.\u003cbr\u003e\nApelin has connections to cardiovascular disorders and metabolic syndrome. High apelin levels have been observed in heart failure indicating its compensatory role in maintaining cardiovascular function. Additionally disruptions in apelin signaling may link to obesity-related diabetes given its effects on insulin sensitivity and energy metabolism. The interplay between apelin APJ and angiotensin II type 1 receptor highlights its potential as a therapeutic target for managing these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851269918889,"sku":"ab189823","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab189823","provider":"Iright","version":"1.0","type":"link"}