{"product_id":"abcam-ab189960","title":"Abcam, ab189960, Anti-FOXH1 antibody - N-terminal","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nRabbit Polyclonal FOXH1 antibody. N-terminal. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human FOXH1.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human FOXH1. The exact immunogen used to generate this antibody is proprietary information.O75593,\u003cbr\u003e\nSpecificity:ab189960 is predicted to not cross-react with any other members of the forkhead box family.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe transcription factor FOXH1 also known as Forkhead Box H1 FOXH1a or Fast-1 plays a significant mechanical role in gene regulation. With a mass of approximately 45 kDa FOXH1 is expressed in various tissues including embryonic and adult tissues. It particularly localizes in the nucleus reflecting its function in modulating the expression of target genes through DNA binding.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFOXH1 functions as an essential component in cell signaling by acting as a transcriptional activator. It interacts with other proteins as part of the transforming growth factor-beta (TGF-β) signaling pathway to influence cell fate determination and development. FOXH1 operates within complexes partnering frequently with SMAD2 and SMAD3 to effectively mediate cellular responses to extracellular signals.\u003cbr\u003e\nPathways\u003cbr\u003e\nFOXH1 occupies a critical position within the TGF-β signaling and Nodal signaling pathways. These pathways are deeply involved in embryonic patterning and the regulation of cell cycle progression. FOXH1 interacts with proteins such as SMAD2 SMAD4 and NODAL which work together to activate specific gene sets essential for embryonic development and tissue homeostasis.\u003cbr\u003e\nFOXH1 links with conditions rooted in developmental defects and cancer. Mutations or dysregulation in FOXH1 expression associate with congenital disorders affecting the heart and other organs. Also its interaction with proteins like NODAL and SMAD factors implicates it in the progression of certain cancers by promoting aberrant cell proliferation and differentiation. Understanding FOXH1's role in these processes aids in the development of targeted therapeutic strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854382485673,"sku":"ab189960","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab189960","provider":"Iright","version":"1.0","type":"link"}