{"product_id":"abcam-ab190369","title":"Abcam, ab190369, Anti-Mouse IgM antibody [RM109]","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Recombinant Monoclonal IGHM antibody. Suitable for ICC, IP, Flow Cyt, ELISA, IHC-P and reacts with Mouse, Recombinant fragment, Recombinant full length protein - Mouse samples. Cited in 9 publications. Immunogen corresponding to Full Length Protein corresponding to Mouse Ighm.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:RM109,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse,\u003cbr\u003e\nApplications:ELISA, IHC-P, ICC, Flow Cyt, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Full Length Protein corresponding to Mouse Ighm. The exact immunogen used to generate this antibody is proprietary information.P01872,\u003cbr\u003e\nSpecificity:This antibody reacts to mouse IgM. No cross reactivity with mouse IgG1, IgG2a, IgG2b, IgG3, IgA, IgE, human IgG, rat IgG, or goat IgG. The Fc region of RM109 has been engineered to eliminate the binding of Fc receptor.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Purification notes-ab190369 was purified from an animal origin–free and protein-free culture supernatant., Storage buffer-Preservative: 0.09% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMouse IgM also known as Immunoglobulin M is an essential type of antibody found in mice with a molecular mass of approximately 970 kDa. This antibody is mainly expressed in the blood and lymphatic fluid and is the first antibody produced by B cells upon exposure to an antigen. The pentameric form of Mouse IgM has ten antigen-binding sites which enhances its ability to neutralize pathogens effectively and forms the foundation of the initial immune response.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMouse IgM acts as a pivotal component in the body's defense mechanisms against infections. It forms part of a complex known as the complement system particularly activating the classic complement pathway. This activation facilitates opsonization where pathogens are marked for ingestion and destruction by macrophages and other immune cells. Alongside IgG antibodies Mouse IgM plays a vital role in immune surveillance and rapid response to foreign antigens although IgM is larger and less specialized compared to its IgG counterpart.\u003cbr\u003e\nPathways\u003cbr\u003e\nMouse IgM is critically connected to the classical complement activation pathway and the B cell signaling pathway. In the complement cascade it interacts with C1 complex beginning the process of pathogen elimination. In the context of B cell receptor-mediated signaling IgM antibodies serve as receptors on naive B cells synergizing with proteins such as Ig-alpha and Ig-beta to initiate signaling cascades essential for B cell maturation and differentiation. These pathways ensure the development of a robust adaptive immune response.\u003cbr\u003e\nDysfunction or deficiency in Mouse IgM can lead to conditions such as immunodeficiencies and autoimmune disorders. For instance a lack of functional IgM results in hyper-IgM syndrome where there is an elevated level of IgG but low levels of IgM impacting the body's ability to fight infections. Additionally systemic lupus erythematosus an autoimmune disease is often associated with abnormal IgM activity. During this condition improper interaction with IgG may exacerbate autoantibody production highlighting the complex relationship between IgM and other immunoglobulins in managing immune health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848562200745,"sku":"ab190369","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab190369","provider":"Iright","version":"1.0","type":"link"}