{"product_id":"abcam-ab190775","title":"Abcam, ab190775, Anti-Hepcidin + Hepcidin-2 antibody [EPR18937]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal HEPC2 antibody. Suitable for WB, IHC-Fr, IHC-P and reacts with Recombinant fragment - Mouse, Mouse samples. Cited in 10 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR18937,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse,\u003cbr\u003e\nApplications:WB, IHC-Fr, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHepcidin also known as LEAP-1 and Hepcidin-2 are small peptides with Hepcidin having a mass of approximately 2.8 kDa. These peptides synthesize in the liver and release into the circulatory system. Hepcidins regulate iron homeostasis by binding to the iron exporter ferroportin which is present on the surface of enterocytes macrophages and hepatocytes. This binding causes ferroportin internalization and degradation reducing iron release into the bloodstream.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe iron-regulating proteins are key regulators of systemic iron metabolism. Hepcidin acts as a hormone controlling the distribution of iron a vital element for many physiological processes. Hepcidin-2 serves a similar role but its specific role is less defined compared to Hepcidin. Though they don't form complexes with other proteins their activity is critical for maintaining controlled levels of iron throughout the body preventing both deficiency and overload.\u003cbr\u003e\nPathways\u003cbr\u003e\nHepcidin and Hepcidin-2 are integral within the iron and hepcidin regulatory pathway which coordinates body iron levels. They play roles in the bone morphogenetic protein (BMP) signaling pathway. The pathway involves several other proteins like BMP6 and SMAD4 which influence hepcidin expression in response to iron levels and the body's erythropoietic activity.\u003cbr\u003e\nHepcidin regulation has implications in conditions like hereditary hemochromatosis and anemia of inflammation. Hereditary hemochromatosis results from insufficient Hepcidin activity leading to iron overload. Conversely anemia of inflammation shows increased Hepcidin levels reducing iron availability and contributing to anemia. Hepcidin dysregulation connects to other proteins such as HFE and transferrin receptor 2 which play roles in iron overload disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844142485673,"sku":"ab190775","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab190775","provider":"Iright","version":"1.0","type":"link"}