{"product_id":"abcam-ab191394","title":"Abcam, ab191394, Anti-Ikaros antibody [EPR13790]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nAnti-Ikaros antibody [EPR13790] (ab191394) is a rabbit monoclonal antibody detecting Ikaros in  Western Blot, Flow Cytometry (Intra), Flow Cytometry, IHC-P . Suitable for  Human, Mouse . - KO validated for confirmed specificity - Biophysical QC for unrivalled batch-batch consistency\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR13790,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-Ikaros antibody [EPR13790] (ab191394) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-P) in Human, Mouse samples.\u003cbr\u003e\nWhat is the molecular weight of Ikaros?\u003cbr\u003e\nAnti-Ikaros [EPR13790] (ab191394) specifically detects a band for Ikaros (UniProt: Q13422) at a molecular weight of 58kDa.\u003cbr\u003e\nTrial sizes available!\u003cbr\u003e\nTest your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.\u003cbr\u003e\nDiscover our selection of trial-size antibodies\u003cbr\u003e\nSpecificity confirmed\u003cbr\u003e\nThe specificity of Anti-Ikaros antibody [EPR13790] (ab191394) has been confirmed by Western blot testing in IKZF1 Knockout Jurkat cells.\u003cbr\u003e\nOther related products\u003cbr\u003e\nWe have a range of other formats of antibody clone [EPR13790] also available for your convenience: ab191394, Carrier free -\u003cbr\u003e\nab206645\u003cbr\u003e\n, PE -\u003cbr\u003e\nab306120\u003cbr\u003e\n, APC -\u003cbr\u003e\nab306121\u003cbr\u003e\n, HRP -\u003cbr\u003e\nab306122\u003cbr\u003e\n, Alkaline Phosphatase -\u003cbr\u003e\nab308943\u003cbr\u003e\n, Alexa Fluor® 488 -\u003cbr\u003e\nab309879\u003cbr\u003e\n, Alexa Fluor® 647 -\u003cbr\u003e\nab310246\u003cbr\u003e\n, Alexa Fluor® 594 -\u003cbr\u003e\nab310699\u003cbr\u003e\n, Alexa Fluor® 555 -\u003cbr\u003e\nab312229\u003cbr\u003e\n, Alexa Fluor® 568 -\u003cbr\u003e\nab312718\u003cbr\u003e\n, Alexa Fluor® 750 -\u003cbr\u003e\nab321321\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nIkaros also known as IKZF1 is a transcription factor. You also find it being referred to as the Ikaros protein or Ikaros code. It has a molecular mass of about 58-60 kDa. Ikaros expresses mostly in hematopoietic cells including precursors from which various blood cell types derive. It plays a significant role in regulating gene expression and cellular differentiation modulating the chromatin structure to control access to DNA.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nIkaros protein functions in the regulation of lymphoid cell development. It is a part of a chromatin-remodeling complex influencing chromatin accessibility. Through its zinc finger domains it binds to specific DNA sequences controlling genes necessary for lymphocyte differentiation and proliferation. Ikaros influences various cell types within the immune system especially affecting T and B cell development and also regulates cytokine receptor genes necessary for proper immune function.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe Ikaros protein is critical to lymphocyte signaling pathways particularly the JAK\/STAT and NF-κB pathways. In these pathways Ikaros interacts with other transcription factors like GATA3 and STAT5 integrating signals that are important for immune cell function and development. This integration allows a coordinated response to extracellular signals ensuring effective immune responses or tolerance.\u003cbr\u003e\nIkaros is associated with leukemia and lymphomas. Alterations or mutations in ikaros gene can lead to misregulation of its target genes contributing to the development of these diseases by disturbing normal hematopoietic processes. Moreover its interaction with TAL1 protein is significant in certain leukemias where disturbances in the balance of their activities can lead to malignancies. Understanding Ikaros's role provides insights for therapeutic approaches in these blood disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850214068393,"sku":"ab191394","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab191394","provider":"Iright","version":"1.0","type":"link"}