{"product_id":"abcam-ab191423","title":"Abcam, ab191423, Anti-ADCY9\/AC9 antibody [EPR16188]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal ADCY9\/AC9 antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 11 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR16188,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nADCY9 also known as AC9 is an enzyme involved in catalyzing the conversion of ATP to cyclic AMP (cAMP) an important secondary messenger in many cellular processes. The protein has a molecular mass of approximately 135 kDa. It is expressed in various tissues with high levels in the brain and immune cells. ADCY9 exhibits unique regulatory properties compared to other members of the adenylyl cyclase family making its study significant for understanding cellular signaling.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nADCY9 plays a central role in the regulation of cAMP which mediates various physiological responses such as hormone signaling and neurotransmission. ADCY9 does not form part of a multi-protein complex but interacts dynamically with G-protein coupled receptors (GPCRs) and protein kinases that modulate its activity and consequently cAMP levels. These interactions influence cellular responses to external stimuli and ensure precise modulation of intracellular signaling pathways.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe regulation of cAMP production by ADCY9 impacts key signaling pathways like the protein kinase A (PKA) pathway and the cyclic AMP response element-binding protein (CREB) pathway. ADCY9 activity affects PKA activation which then phosphorylates various target proteins altering their function and activity. Similarly ADCY9's role in the CREB pathway through cAMP influences gene transcription related to cell survival and differentiation. This places ADCY9 at a significant point in mediating cellular response to hormonal and environmental signals.\u003cbr\u003e\nAltered ADCY9 expression or function has been linked to conditions such as asthma and heart disease. Variations in ADCY9 can affect cAMP-mediated signaling pathways implicated in the pathophysiology of these diseases. Additionally the interaction between ADCY9 and G-proteins especially in immune cells suggests potential involvement in inflammation-related conditions. Understanding the role of ADCY9 in these disorders can contribute to the development of targeted therapies that modulate its activity providing a potential therapeutic approach.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848551551145,"sku":"ab191423","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab191423","provider":"Iright","version":"1.0","type":"link"}