{"product_id":"abcam-ab191424","title":"Abcam, ab191424, Anti-ACAP2 antibody [EPR15721]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal ACAP2 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Mouse, Rat, Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR15721,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nACAP2 also known as ArfGAP with coiled-coil ankyrin repeat and PH domain-containing protein 2 plays a role in cell signaling and membrane trafficking. It has a molecular mass of around 90 kDa and is expressed in various tissues including the brain and kidney. ACAP2 acts as a GTPase-activating protein (GAP) for ADP-ribosylation factor 6 (Arf6) a member of the Arf family which is important in vesicle formation in cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nACAP2 influences cellular processes by regulating actin cytoskeleton remodeling and endocytosis. It is part of a complex that interacts with proteins like phosphatidylinositol 45-bisphosphate which helps localize ACAP2 to specific cellular membranes. The protein's ability to bind and hydrolyze GTP enables changes in cell shape and movement contributing to cellular migration and morphological adjustments.\u003cbr\u003e\nPathways\u003cbr\u003e\nACAP2 participates in the endocytic pathway which is important for internalizing substances into the cell. It is also involved in the signaling pathway related to the actin cytoskeleton impacting cell motility. In these pathways ACAP2 interacts with proteins such as Arf6 facilitating its function as a regulator of endocytosis and actin dynamics.\u003cbr\u003e\nACAP2 has been linked to cancer and neurodegenerative diseases. Dysregulation of ACAP2 and its associated proteins like Arf6 can lead to changes in cell adhesion and motility processes often altered in tumor progression. Additionally aberrant ACAP2 function can interfere with normal neurological processes possibly contributing to the pathology of neurodegenerative disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850297135273,"sku":"ab191424","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab191424","provider":"Iright","version":"1.0","type":"link"}