{"product_id":"abcam-ab191871","title":"Abcam, ab191871, Anti-REDD-1\/DDIT4 antibody [EPR18716]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal REDD-1\/DDIT4 antibody. Suitable for IP, WB, ICC\/IF and reacts with Human samples. Cited in 12 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR18716,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nREDD-1 also known as DDIT4 (DNA Damage Inducible Transcript 4) is a protein involved in cellular response to stress particularly hypoxic conditions. It has a molecular weight of approximately 35 kDa. This protein is expressed in various tissues including the brain liver and muscle indicating its importance in different physiological environments. REDD-1 acts as a negative regulator of the mechanistic target of rapamycin (mTOR) signaling pathway which plays an important role in cell growth and survival.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe role of REDD-1 involves its participation in cellular adaptation to stress by inhibiting mTORC1 a complex within the mTOR pathway. Through this mechanism it helps cells to survive in limiting conditions by adjusting metabolic and growth signals. REDD-1 is not part of a larger protein complex but interacts closely with components of the mTOR pathway. Its regulation ensures proper cellular function under stress making it an important point for controlling cell behavior.\u003cbr\u003e\nPathways\u003cbr\u003e\nREDD-1 serves as a significant regulator in the mTOR signaling and cellular stress response pathways. REDD-1 inhibits mTORC1 activity facilitating the cellular adaptation under nutrient starvation and hypoxic conditions. This inhibition affects the phosphorylation of downstream targets like S6K1 and 4EBP1 which are important for protein synthesis. Moreover REDD-1's relationship with the AMP-activated protein kinase (AMPK) adds another layer of regulation in energy balance and metabolic control.\u003cbr\u003e\nREDD-1's dysregulation links to cancer and neurodegenerative diseases. In cancer altered REDD-1 expression affects mTORC1 signaling which can lead to unregulated cell growth and proliferation. The protein is connected to hypoxia-inducible factor (HIF) which contributes to tumor growth in hypoxic environments. In neurodegenerative diseases improper stress responses involving REDD-1 may exacerbate neuronal damage. Understanding REDD-1's interactions with mTORC1 and HIF could offer insights into potential therapeutic targets for these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844078751913,"sku":"ab191871","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab191871","provider":"Iright","version":"1.0","type":"link"}