{"product_id":"abcam-ab191891","title":"Abcam, ab191891, Anti-MRPS18B antibody [EPR19298]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal MRPS18B antibody. Suitable for IP, WB, ICC\/IF and reacts with Human, Mouse, Rat samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR19298,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IP, ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe MRPS18B protein also known as mitochondrial ribosomal protein S18B is a component of the mitochondrial ribosome with a molecular mass of approximately 27 kDa. This protein is an integral part of the small subunit of the mitochondrial ribosome (28S) which plays a role in protein synthesis within mitochondria. MRPS18B is expressed mainly in tissues with high energy demands such as the heart and skeletal muscle given its function in energy production.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nProteins like MRPS18B are essential in maintaining mitochondrial function. MRPS18B operates within the ribosomal complex enabling the translation of mitochondrial-encoded genes necessary for proper cellular respiration. This role is critical for ATP production which supports numerous cellular processes. It shares functional similarities with other mitochondrial ribosomal proteins and together they ensure the synthesis of key components of the oxidative phosphorylation machinery.\u003cbr\u003e\nPathways\u003cbr\u003e\nMRPS18B plays a significant role in the mitochondrial translation pathway. This pathway is important for the production of proteins encoded by the mitochondrial genome which are vital for the oxidative phosphorylation pathway. MRPS18B collaborates closely with other mitochondrial ribosomal proteins to facilitate accurate mRNA translation and is indirectly linked to the expression of proteins in the electron transport chain such as cytochrome c oxidase.\u003cbr\u003e\nAbnormalities in MRPS18B expression or function can impact mitochondrial efficiency and have been connected to mitochondrial diseases such as Leigh syndrome. This syndrome is a neurodegenerative disorder that severely affects energy production in cells. MRPS18B also shows a relationship with Parkinson's disease where mitochondrial dysfunction plays a pivotal role with interactions noted between MRPS18B and proteins involved in mitochondrial maintenance such as PINK1 and Parkin.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850314076329,"sku":"ab191891","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab191891","provider":"Iright","version":"1.0","type":"link"}