{"product_id":"abcam-ab192235","title":"Abcam, ab192235, Anti-NDUFAF5 antibody [EPR15870] - C-terminal","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal NDUFAF5 antibody. C-terminal. Suitable for IP, WB, ICC\/IF, Flow Cyt (Intra), IHC-P and reacts with Human, Mouse samples. Cited in 3 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR15870,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:IP, IHC-P, WB, Flow Cyt (Intra), ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNDUFAF5 also known as NADH:ubiquinone oxidoreductase complex assembly factor 5 is a mitochondrial protein with a mass of approximately 34 kDa. The protein plays a mechanical role in the assembly of the mitochondrial complex I also termed NADH dehydrogenase. It's necessary for the assembly of this critical component of the electron transport chain which is fundamental for cellular energy production. NDUFAF5 is expressed in various tissues with significant expression in energy-demanding organs such as the heart and brain.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNDUFAF5 participates in the assembly of complex I an essential part of mitochondrial oxidative phosphorylation. This complex is a multi-subunit structure where NDUFAF5 functions as an important assembly factor interacting with precursor subunits to help build the complex properly. It coordinates the junction of early-stage assembly intermediates working closely with assembly proteins like NDUFAF1 to ensure the formation and maintenance of efficient electron transport.\u003cbr\u003e\nPathways\u003cbr\u003e\nNDUFAF5 is an important player in the mitochondrial oxidative phosphorylation pathway and the electron transport chain. These pathways are responsible for ATP production through the transfer of electrons from NADH to oxygen. NDUFAF5 ensures that complex I integrates correctly into the pathway assisting with proper electron and proton flow. Mitochondrial proteins such as NDUFS1 and CYCS interact closely with NDUFAF5 within these pathways contributing to normal cellular respiration and energy metabolism.\u003cbr\u003e\nDysfunctions in NDUFAF5 are linked with complex I deficiency and mitochondrial disorders such as Leigh syndrome. These conditions can result in severe energy production impairments leading to neurological symptoms and muscle weakness. Mutations in NDUFAF5 can alter interactions with assembly proteins such as NDUFAF1 affecting the stability and function of the entire complex I. Observing the involvement of NDUFAF5 could provide insights into the pathological mechanisms of mitochondrial-related diseases and aid in therapeutic development.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850293399721,"sku":"ab192235","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab192235","provider":"Iright","version":"1.0","type":"link"}