{"product_id":"abcam-ab192612","title":"Abcam, ab192612, Anti-ATP6V1B1 antibody [EPR16400]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal ATP6V1B1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human, Rat samples. Cited in 7 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR16400,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nATP6V1B1 also known as V-type proton ATPase subunit B1 is an important component of the vacuolar ATPase (V-ATPase) complex. It plays an important role in the acidification of intracellular compartments by facilitating proton translocation across membranes. The molecular mass of ATP6V1B1 is approximately 58 kDa. ATP6V1B1 expresses prominently in the kidney specifically in the epithelial cells of the distal tubules and collecting ducts as well as in the inner ear.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nATP6V1B1 is involved in cellular processes that require the maintenance of pH gradients across membranes. It forms part of the V-ATPase complex which consists of multiple subunits working together to pump protons into the vacuoles and other organelles effectuating an acidic environment. These acidic environments are important for protein sorting zymogen activation and receptor-mediated endocytosis.\u003cbr\u003e\nPathways\u003cbr\u003e\nATP6V1B1 contributes directly to the endocytic and lysosomal degradation pathways playing an essential role in cellular homeostasis. The protein interacts with other V-ATPase subunits such as ATP6V1E1 and ATP6V1C1 within these pathways to ensure the proper functioning of organelles. It also assists in maintaining the acidification essential for the processing and transport of molecules inside cells.\u003cbr\u003e\nMutations in the ATP6V1B1 gene associate strongly with distal renal tubular acidosis (dRTA) and sensorineural hearing loss. In dRTA disrupted acidification in the kidney impairs the body's ability to excrete acids or balance pH. Furthermore ATP6V1B1's interaction with proteins like ATP6V0A4 is significant as mutations in both proteins are linked to a similar disorder highlighting their role in maintaining renal and auditory function.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855857143977,"sku":"ab192612","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab192612","provider":"Iright","version":"1.0","type":"link"}