{"product_id":"abcam-ab192643","title":"Abcam, ab192643, Alexa Fluor® 488 Anti-Cytokeratin 19 antibody [EP1580Y]","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nAnti-Cytokeratin 19 antibody [EP1580Y] - Alexa Fluor® 488 conjugated (ab192643) is a rabbit recombinant monoclonal antibody detecting Cytokeratin 19 in  Flow Cytometry (Intra), Flow Cytometry, ICC\/IF . Suitable for  Human . - KO validated for confirmed specificity - Biophysical QC for unrivalled batch-batch consistency\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EP1580Y,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nConjugation:Alexa Fluor® 488,\u003cbr\u003e\nExcitation\/Emission:Ex: 495nm, Em: 519nm,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, Flow Cyt (Intra), ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAlexa Fluor® 488 Anti-Cytokeratin 19 antibody [EP1580Y] (ab192643) is a rabbit recombinant monoclonal antibody and is validated for use in Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunocytochemistry\/immunofluorescence (ICC\/IF) in Human samples.\u003cbr\u003e\nRelated products\u003cbr\u003e\nAntibody clone EP1580Y is also available pre-conjugated to a variety of labels for your convenience – Anti-Cytokeratin 19 Alexa Fluor® 488 [EP1580Y] (ab192643).\u003cbr\u003e\nSpecificity confirmed\u003cbr\u003e\nThe specificity of Alexa Fluor® 488 Anti-Cytokeratin 19 antibody [EP1580Y] (ab192643) has been confirmed by Immunocytochemistry testing in Cytokeratin 19 Knockout MCF7 cells.\u003cbr\u003e\nOther related products\u003cbr\u003e\nWe have a range of other formats of antibody clone [EP1580Y] also available for your convenience:\u003cbr\u003e\nab52625\u003cbr\u003e\n, Alexa Fluor® 488 - ab192643, Alexa Fluor® 647 -\u003cbr\u003e\nab192980\u003cbr\u003e\n, HRP -\u003cbr\u003e\nab193600\u003cbr\u003e\n, Carrier free -\u003cbr\u003e\nab195872\u003cbr\u003e\n, Alexa Fluor® 594 -\u003cbr\u003e\nab203443\u003cbr\u003e\n, Alexa Fluor® 555 -\u003cbr\u003e\nab203444\u003cbr\u003e\n, Alexa Fluor® 568 -\u003cbr\u003e\nab203445\u003cbr\u003e\n, APC -\u003cbr\u003e\nab224980\u003cbr\u003e\n, PE -\u003cbr\u003e\nab224981\u003cbr\u003e\n, Carrier free - ab302465,\u003cbr\u003e\nab323561\u003cbr\u003e\nab323562\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nAlexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle, Stable for 12 months at -20°C, Store in the dark\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCytokeratin 19 (CK19) also known as cytokera­tine 19 keratin 19 (KRT19) or CK19 is a type of intermediate filament found in epithelial cells. It serves as an essential component of the cytoskeleton. CK19 weighs approximately 40 kDa and is broadly expressed in simple epithelial tissues including liver intestine and various glandular epithelial cells. As a cytokeratin marker it often appears in combination with others like cytokeratin 17 in certain tissue types helping to maintain the structural integrity of cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCK19 plays a role in maintaining the cytoskeletal framework that provides mechanical support and helps control cell size and shape. It is not part of a large protein complex but works closely with other cytokeratins to ensure the stability and resilience of epithelial tissues. The A53-B\/A22.26 positive staining is often used to confirm its presence in clinical histopathology.\u003cbr\u003e\nPathways\u003cbr\u003e\nCK19 connects to cellular processes especially involving the keratinization and epithelial cell differentiation pathways. It interacts with other cytokeratins including BA16 and KR17 to facilitate these processes. This interaction aids in modulating the dynamics of cytoskeletal rearrangement during cell movement division and differentiation.\u003cbr\u003e\nCK19 overexpression is linked with certain cancers notably hepatocellular carcinoma and breast cancer. It can serve as a prognostic marker in these diseases often in conjunction with other markers like CK17. The involvement of CK19 in the epithelial-mesenchymal transition (EMT) process connects it to the progression and aggressiveness of tumors facilitated by interactions with proteins involved in EMT pathways.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844216639657,"sku":"ab192643","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab192643","provider":"Iright","version":"1.0","type":"link"}