{"product_id":"abcam-ab192868","title":"Abcam, ab192868, Anti-ERAS antibody [EPR15595]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal ERAS antibody. Suitable for WB and reacts with Human, Mouse samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR15595,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nERAS also known as Embryonic Stem Cell Ras (EC-Ras) is a member of the Ras protein family. It has a molecular weight of approximately 23 kDa. ERAS is mainly expressed in embryonic stem cells and specific cancer cells. It shares structural similarities with other Ras family proteins having a low GTPase activity that contributes to its role as a molecular switch in signaling pathways. Like other Ras proteins ERAS toggles between active GTP-bound and inactive GDP-bound forms which influences downstream signaling pathways.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe ERAS protein influences cell proliferation survival and growth in tissues where it is expressed. It is not part of a larger protein complex but rather acts independently to stimulate the phosphoinositide 3-kinase (PI3K) pathway. This activation of the PI3K pathway leads to the downstream activation of Akt a critical effector in cellular growth and survival processes. By promoting these cellular functions ERAS contributes to maintaining the self-renewal properties of stem cells and influencing oncogenic processes in cancer cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nERAS engages actively with the PI3K\/Akt signaling pathway facilitating the survival and growth of cells. It directly interacts with the PI3K protein promoting cellular proliferation. Additionally ERAS has interactions with the MAPK\/ERK pathway a well-known pathway linked to cell division and differentiation. The interaction between these pathways involves proteins like Raf and MEK which integrates growth signals coming from activated Ras proteins.\u003cbr\u003e\nERAS expression has been associated with certain types of cancers notably germ cell tumors and possibly breast cancer. Through its interaction with the PI3K\/Akt signaling pathway ERAS contributes to the oncogenic properties observed in these cancers. Moreover its activities can influence the behavior of proteins such as PTEN and p53 which are well known for their tumor suppressor functions. The modulation of these pathways and interactions ultimately affect cellular processes like apoptosis which can contribute to the development and progression of cancer.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850312208553,"sku":"ab192868","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab192868","provider":"Iright","version":"1.0","type":"link"}