{"product_id":"abcam-ab194827","title":"Abcam, ab194827, Anti-RAB45 antibody [EPR16349]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal RAB45 antibody. Suitable for WB, ICC\/IF, Flow Cyt (Intra) and reacts with Mouse, Rat, Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR16349,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WB, Flow Cyt (Intra), ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRAB45 also known as RASEF is a member of the Ras superfamily of small GTPases. This protein has a molecular mass of approximately 83 kDa. It regulates various cellular processes by cycling between inactive GDP-bound and active GTP-bound states. RAB45 primarily localizes to intracellular membranes including endosomes and lysosomes. It is highly expressed in tissues such as the brain and pancreas indicating its role in specific cellular functions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRAB45 participates in intracellular trafficking ensuring proper vesicle flow and cargo delivery in the cell. It may associate with various effector proteins forming complexes needed for its function. Its role in membrane trafficking links it to pathways involving cellular signaling and homeostasis. RAB45 helps maintain cellular organization by managing membrane-bound compartments which is important for the effective function of endosomal and lysosomal pathways.\u003cbr\u003e\nPathways\u003cbr\u003e\nRAB45 plays roles in vesicular transport and endocytic recycling processes. It interacts within the Rab family pathways that facilitate membrane trafficking. RAB45 is closely related to other Rab family proteins such as RAB7 and RAB9 which also regulate endosomal and lysosomal pathways. These interactions ensure coordination of intracellular transport and recycling processes necessary for cellular maintenance and function.\u003cbr\u003e\nRAB45 shows associations with certain neurological disorders and cancer types. Altered expression levels of RAB45 have been reported in glioblastoma suggesting its potential role in tumor progression. Additionally RAB45 might influence Alzheimer's disease by impacting vesicular pathways tied to APP processing. Connections with proteins such as tau in neurodegenerative pathways highlight the possible implications of RAB45 dysregulation in disease states.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850326069417,"sku":"ab194827","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab194827","provider":"Iright","version":"1.0","type":"link"}