{"product_id":"abcam-ab195236","title":"Abcam, ab195236, Anti-TAF5 antibody [EPR15433] - C-terminal","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal TAF5 antibody. C-terminal. Suitable for IP, WB, Flow Cyt (Intra) and reacts with Human, Rat, Mouse samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR15433,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTAF5 also known as TAFII100 is a component of the transcription factor IID complex and is vital in the process of assembling the pre-initiation complex for gene transcription. This protein has a molecular mass of approximately 100 kDa. It is prominently expressed in a variety of tissues such as liver and heart indicating its broad functional significance in various cellular environments. TAF5 through its structural role helps stabilize the TFIID complex facilitating the binding of transcription machinery to DNA promoters.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTAF5 forms part of the TFIID complex a cornerstone for gene transcription initiation. TFIID is one of the basal transcription factors essential for RNA polymerase II to carry out transcription of mRNA. The proper assembly and functioning of TFIID rely heavily on TAF5 as it interacts with other TAFs and the TBP (TATA-box Binding Protein) enabling accurate transcriptional regulation. This process impacts the expression of a large number of genes highlighting TAF5's broad biological utility and influence.\u003cbr\u003e\nPathways\u003cbr\u003e\nTAF5 plays a major role in the transcription initiation pathway and is an active participant in the RNA polymerase II transcription machinery. It associates closely with TAF6 and TAF9 within the TFIID complex facilitating the recruitment of other proteins to initiate transcription. Through these interactions TAF5 impacts the cell cycle control and apoptosis pathways modulating cellular responses to developmental cues and environmental stresses. These pathways illustrate the importance of TAF5 in maintaining cellular homeostasis and responding to physiological signals.\u003cbr\u003e\nTAF5 has associations with cancer and certain neurodegenerative diseases. Aberrant expression or mutations in the TAF5 gene may disrupt the transcriptional machinery leading to uncontrolled cellular proliferation or neuronal cell death. For example in cancer TAF5's interaction with TIP60 a histone acetyltransferase modifies chromatin structure influencing tumorigenic processes. Meanwhile in neurodegenerative disorders impaired TAF5 functions might alter gene expression patterns important for neuronal survival linking TAF5 to the disease pathology and progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850300936361,"sku":"ab195236","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab195236","provider":"Iright","version":"1.0","type":"link"}