{"product_id":"abcam-ab196136","title":"Abcam, ab196136, Recombinant human CECR2 protein (Active)","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRecombinant human CECR2 protein (Active) is a Human Fragment protein, in the 430 to 543 aa range, expressed in Escherichia coli, with \u0026gt;95%, suitable for SDS-PAGE, FuncS.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;95% SDS-PAGE,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:His tag N-Terminus,\u003cbr\u003e\nApplications:FuncS, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:Yes,\u003cbr\u003e\nBiological activity:Active,\u003cbr\u003e\nAccession:Q9BXF3,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.48% Tris, 0.04% Sorbitan monolaurate, ethoxylated, 0.02% Potassium chloride\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe CECR2 protein also known as Cat Eye Syndrome Chromosome Region Candidate 2 plays an important role in chromatin remodeling. It has a molecular mass of approximately 150 kDa. This protein functions as part of the CECR2-containing complex (CERF) which takes part in the regulation of nucleosome catalysis. CECR2 expresses in various tissues with notable expression in the testis brain and fetal tissue.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe CECR2 protein engages in modulating transcriptional activity influencing the accessibility of DNA for transcription machinery. It acts as a component of the CERF complex integrating with multiple other proteins to facilitate these transcriptional adjustments. This action directly affects gene expression patterns critical for developmental processes particularly in neurogenesis and spermatogenesis.\u003cbr\u003e\nPathways\u003cbr\u003e\nCECR2 interacts in the chromatin remodeling pathways essential for DNA replication and repair. The protein associates with SWI\/SNF-like chromatin-remodeling complexes. These complexes enhance the efficient binding of transcriptional factors such as those of the BRG1\/BRM-associated factor (BAF) complex. This interaction supports regulatory processes in embryonic development and cellular differentiation.\u003cbr\u003e\nCECR2 mutations or dysregulation have strong links to neural tube defects and Cat Eye Syndrome. Neural tube defects result from improper closure of the neural tube during early embryonic development where CECR2 plays a regulatory role. The protein also relates to conditions involving altered chromatin structure. CECR2's relationship with other proteins involved in neural tube closure disorders like SHH (Sonic Hedgehog) highlights its relevance in these pathologies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843967963305,"sku":"ab196136","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab196136","provider":"Iright","version":"1.0","type":"link"}