{"product_id":"abcam-ab196275","title":"Abcam, ab196275, Anti-PRELID1 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal PRELID1 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PRELID1 aa 50-200.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human PRELID1 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.Q9Y255\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.02% Sodium azideConstituents: 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPRELID1 also known as SLMO2 is a mitochondrial phospholipid transfer protein. This protein has a molecular mass of approximately 22 kDa and is expressed in various tissues with notable presence in the liver heart and skeletal muscle. Mechanically PRELID1 transfers phosphatidic acid from the outer to the inner mitochondrial membrane a process fundamental for maintaining mitochondrial lipid homeostasis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPRELID1 operates as part of a larger multi-protein complex within the mitochondria. It associates with other proteins like TRIT1 which together play a role in lipid metabolism and regulation. PRELID1's actions impact the synthesis of cardiolipin a critical lipid for mitochondrial inner membrane structure and function. By participating in these processes PRELID1 ensures proper mitochondrial activity and energy production.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe activity of PRELID1 intersects with key pathways involved in lipid metabolism and mitochondrial function. Notably it plays a role in the CL (cardiolipin) remodeling pathway. Furthermore PRELID1 interacts with proteins such as TAMM41 a phosphatidic acid transfer protein which facilitates cardiolipin biosynthesis. These pathways are essential for the maintenance of mitochondrial membrane potential and cellular energy output.\u003cbr\u003e\nAbnormalities in PRELID1 function connect to mitochondrial-related diseases including Barth syndrome and certain metabolic disorders. Research indicates its malfunction could link to altered cardiolipin synthesis affecting energy metabolism. Proteins involved in these conditions such as tafazzin play a role in cardiolipin remodeling highlighting the importance of PRELID1's function in maintaining healthy mitochondrial dynamics.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850089877673,"sku":"ab196275","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab196275","provider":"Iright","version":"1.0","type":"link"}