{"product_id":"abcam-ab196984","title":"Abcam, ab196984, Anti-IFNL4 antibody [51-1]","description":"\u003cp\u003eSize: 10µg-TRIAL \/ 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal IFNL4 antibody. Suitable for BL, WB and reacts with Human, Synthetic peptide samples. Cited in 10 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:51-1,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, BLSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product has switched from a hybridoma to recombinant production method on 6th January 2021.\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nWant a custom formulation?\u003cbr\u003e\nThis antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nIFNL4 also known as Interferon Lambda 4 plays an important role in the immune system. This protein with a mass of approximately 22 kDa is part of the type III interferon family. It expresses mainly in liver cells and epithelial tissues. IFNL4 is involved in the antiviral defense mechanism of the body. It shows activity by binding to the IFN lambda receptor complex initiating a response that helps control viral infections.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nIFNL4 acts as a cytokine and contributes to modulating immune responses. It is not part of a complex but interacts closely with the IFN lambda receptor to activate Janus kinase and signal transducer and activator of transcription (JAK-STAT) signaling pathways. This activation leads to the promotion of antiviral responses in infected cells and limits viral spread. Understanding its signaling function clarifies its important impact on immune defense.\u003cbr\u003e\nPathways\u003cbr\u003e\nIFNL4 is fundamental to the JAK-STAT signaling pathway and to the innate immune response pathway. These pathways mediate cellular responses to viral infections. IFNL4 interacts with other proteins like IFNLR1 IL10RB and STAT1 which are essential for these pathways. By engaging these pathways IFNL4 helps control the expression of genes involved in antiviral defense such as those coding for interferon-stimulated genes (ISGs).\u003cbr\u003e\nIFNL4 has strong connections to hepatitis C virus (HCV) infection and liver fibrosis. Researchers found that the expression of IFNL4 can influence the outcome of HCV infection affecting viral clearance and treatment response. Another related protein IFNL3 also interacts with these pathways and together they provide insights into the genetic factors influencing liver fibrosis progression. Understanding IFNL4's role provides opportunities to develop targeted therapies for these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850269905065,"sku":"ab196984","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab196984","provider":"Iright","version":"1.0","type":"link"}