{"product_id":"abcam-ab197260","title":"Abcam, ab197260, Anti-PSTPIP1 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal PSTPIP1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PSTPIP1 aa 50-350.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human PSTPIP1 aa 50-350. The exact immunogen used to generate this antibody is proprietary information.O43586\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Lyophilized, Reconstitution-reconstitute with water at 200µL, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPSTPIP1 also known as Proline-Serine-Threonine Phosphatase Interacting Protein 1 is a cytoplasmic adaptor protein with a molecular weight of approximately 47 kDa. It mainly functions in the regulation of the actin cytoskeleton. This protein contains an F-BAR domain and a SH3 domain allowing it to bind membranes and other proteins affecting cytoskeletal dynamics. PSTPIP1 is expressed in various tissues including hematopoietic cells where it plays significant roles in immune cell function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPSTPIP1 interacts with several proteins to regulate cellular processes including inflammation and cell movement. It is known to bind to PTP-PEST a protein tyrosine phosphatase which plays a role in cytoskeletal organization. PSTPIP1 is also found in complexes that can alter the actin cytoskeleton influencing cell adhesion and motility. This interaction impacts immune responses and signaling pathways in cells playing an important role in maintaining cellular integrity under various physiological conditions.\u003cbr\u003e\nPathways\u003cbr\u003e\nPSTPIP1 contributes to the regulation of the actin cytoskeleton and inflammatory pathways. It participates in the signaling pathways that involve the Wiskott-Aldrich syndrome protein (WASP) which connects to actin polymerization processes. Additionally PSTPIP1 links with the proteins in the NF-kB pathway participating in the modulation of immune responses. This positioning in multiple pathways allows PSTPIP1 to influence cellular responses significantly.\u003cbr\u003e\nPSTPIP1 mutations and dysregulation have been linked to conditions such as pyogenic arthritis pyoderma gangrenosum and acne (PAPA) syndrome. In these diseases PSTPIP1 interacts with proteins such as PTP-PEST and pyrin which are critical in controlling inflammation. Abnormal interactions or mutations in PSTPIP1 can lead to hyperactivation of inflammation contributing to the symptoms observed in these disorders highlighting its important role in immune regulation and pathology.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854248071337,"sku":"ab197260","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab197260","provider":"Iright","version":"1.0","type":"link"}