{"product_id":"abcam-ab197590","title":"Abcam, ab197590, Anti-MBNL3 antibody [EPR16337]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal MBNL3 antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 3 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR16337,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMuscleblind-like protein 3 (MBNL3) mechanically plays a role in RNA splicing and localization. It lacks a popular alternate name in scientific literature. MBNL3 has a mass of 36 kDa and is expressed widely in human tissues with higher expression in skeletal muscle heart and brain. The protein binds RNA via its zinc-finger domains enabling it to influence the processing of pre-mRNA transcripts.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nIn the regulation of gene expression networks MBNL3 modulates alternative splicing and RNA stability. Though not part of a larger multiprotein complex it interacts directly with precursor mRNA specifically affecting splicing events. This regulation is critical in maintaining normal tissue function and development particularly in muscle and neural tissues.\u003cbr\u003e\nPathways\u003cbr\u003e\nMBNL3 impacts RNA processing and stress response pathways. MBNL3 interacts with its homologs MBNL1 and MBNL2 which are part of the same splicing regulatory network. Through these interactions it affects pathways involved in cell differentiation and response to environmental stress contributing to the regulation of gene expression under varying physiological conditions.\u003cbr\u003e\nDefects in MBNL3 function are associated with myotonic dystrophy and certain cancers. In myotonic dystrophy imbalanced splicing caused by malfunction of MBNL proteins including MBNL3 leads to muscular and neurological symptoms. In cancers changes in the expression or activity of MBNL3 might influence tumor progression through its role in splicing regulation. Understanding the connection between MBNL3 and diseases can inform therapeutic target research and potential treatment strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850416050345,"sku":"ab197590","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab197590","provider":"Iright","version":"1.0","type":"link"}