{"product_id":"abcam-ab198499","title":"Abcam, ab198499, Anti-GRID2 antibody [EPR15422] - N-terminal","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal GRID2 antibody. N-terminal. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 4 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR15422,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe gene symbol 'GRID2' encodes the protein Glutamate Receptor Ionotropic Delta-2 commonly called GRID2. It is part of the ionotropic glutamate receptor family and functions as ion channels in the central nervous system. GRID2 has an approximate mass of 110 kDa and is principally expressed in the cerebellum. This protein receptor plays a role in excitatory synaptic transmission by binding glutamate an essential neurotransmitter. It is not widespread in the body but has critical functions where it is present.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe GRID2 protein is significant in synaptic plasticity and cerebellar functions by contributing to synapse formation and stability. It is part of the postsynaptic density (PSD) complex in neurons mainly affecting the communication between neuron cells. This protein helps in maintaining proper synaptic connections necessary for motor coordination and learning. The deficit of GRID2 can disrupt these functions affecting synaptic efficacy and neurological behavior.\u003cbr\u003e\nPathways\u003cbr\u003e\nGrid ionotropic receptors like GRID2 play a pivotal role in the glutamatergic pathway and the synaptic signaling pathway. These pathways have strong associations with synaptic transmission and plasticity influencing learning and memory. The relationship of GRID2 with other proteins such as GRIA1 another glutamate receptor highlights its involvement in regulating synaptic strength and communication between neurons.\u003cbr\u003e\nGRID2 mutations or dysfunctions link to neurological conditions such as spinocerebellar ataxia and autism spectrum disorders. Spinocerebellar ataxia patients show mutations that alter GRID2 function impacting motor coordination. In some autism spectrum disorder cases alterations in GRID2-supported pathways can influence synaptic connectivity which affects cognitive and social functioning. Connections with other proteins like GRIK2 suggest a network where GRID2 dysfunction contributes to these disease symptoms.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850299265193,"sku":"ab198499","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab198499","provider":"Iright","version":"1.0","type":"link"}