{"product_id":"abcam-ab199423","title":"Abcam, ab199423, Anti-ATE1 antibody [EPR13667(2)] - N-terminal","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal ATE1 antibody. N-terminal. Suitable for WB, Flow Cyt (Intra), IHC-P and reacts with Mouse, Rat, Human samples. Cited in 4 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR13667(2),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IHC-P, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nATE1 also known as Arginyltransferase 1 is an important enzyme that plays a mechanical role in cellular processes. It is responsible for adding the amino acid arginine to the N-terminus of certain target proteins a modification important for protein stability and function. ATE1 has a molecular mass of approximately 75 kDa. This enzyme is expressed in various tissues with higher expression levels observed in the heart liver and brain indicating its importance in these areas.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nATE1 acts as a regulator in protein degradation by tagging proteins with arginine marking them for ubiquitination and subsequent proteasomal degradation. This function is critical for controlling the protein turnover and maintaining cellular homeostasis. ATE1 functions independently and is not known to be a part of any larger protein complex emphasizing its specific role in post-translational modification of proteins.\u003cbr\u003e\nPathways\u003cbr\u003e\nThis arginylation process by ATE1 integrates into the ubiquitin-proteasome system a pathway significant for protein catabolism. It plays a role in cellular stress responses linking closely with the protein degradation pathways to control damaged or misfolded proteins. ATE1's activity interacts with proteins such as ubiquitin ligases which assist in the tagging and recognition of proteins for degradation ensuring proper proteostasis.\u003cbr\u003e\nATE1 has been implicated in cardiac hypertrophy and cancer. Altered expression or activity of ATE1 can contribute to the dysregulation of protein turnover in the heart connecting it to cardiac hypertrophy. In cancer abnormal arginylation can affect cellular homeostasis and lead to uncontrollable cell proliferation. ATE1 connects to proteins like N-end rule substrates in the context of these diseases acting as a potential biomarker or therapeutic target for disease intervention.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850288582825,"sku":"ab199423","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab199423","provider":"Iright","version":"1.0","type":"link"}