{"product_id":"abcam-ab199425","title":"Abcam, ab199425, Anti-SSX2IP antibody [EPR16979]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal SSX2IP antibody. Suitable for IP, WB, IHC-P and reacts with Human samples. Cited in 3 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR16979,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IP, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSSX2IP also known as ADIP or SSX2-interacting protein is a protein weighing approximately 73 kDa. It functions mechanically as a centrosomal protein interacting with proteins involved in centrosome duplication and spindle formation. SSX2IP shows expression in various tissues especially in dividing cells highlighting its role in cell cycle regulation. It interacts with proteins like CCDC155 (CEP155) during centrosome dynamics.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSSX2IP facilitates the assembly of the mitotic spindle and the proper segregation of chromosomes during cell division. It is part of a complex where it collaborates with spindle assembly factors to ensure accurate cell division. By supporting centrosome integrity SSX2IP plays a necessary role in maintaining genomic stability and proper cell proliferation.\u003cbr\u003e\nPathways\u003cbr\u003e\nSeveral elements such as cell cycle progression and the SPICE1-interacting pathway rely on SSX2IP. It participates in pathways that oversee centrosome duplication and spindle dynamics making it critical for mitotic progression. SSX2IP interacts with proteins like SPDYA and PLK1 which are key elements in cell cycle-related pathways ensuring the fidelity of cell division.\u003cbr\u003e\nAbnormalities in SSX2IP expression or function may have connections to cancer and neurodevelopmental disorders. In oncology dysregulation of SSX2IP can affect centrosome function and contribute to chromosomal instability a hallmark of many cancers. Additionally its interaction with abnormal centrosomal proteins like ASPM links it to microcephaly affecting neural development. Therefore understanding SSX2IP offers valuable insights into both cancer biology and developmental anomalies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850383675561,"sku":"ab199425","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab199425","provider":"Iright","version":"1.0","type":"link"}