{"product_id":"abcam-ab199428","title":"Abcam, ab199428, Anti-GATA3 antibody [EPR16651] - ChIP Grade","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nAnti-GATA3 antibody [EPR16651] - ChIP Grade (ab199428) is a rabbit monoclonal antibody detecting GATA3 in  Western Blot, Flow Cytometry (Intra), Flow Cytometry, IP, IHC-P, ICC\/IF, ChIP . Suitable for  Human, Mouse . - KO validated for confirmed specificity - Biophysical QC for unrivalled batch-batch consistency - Over 60 publications\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR16651,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Mouse,\u003cbr\u003e\nApplications:ICC\/IF, WB, IHC-P, Flow Cyt (Intra), ChIPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nAnti-GATA3 antibody [EPR16651] - ChIP Grade (ab199428) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in ChIP, Flow Cyt (Intra), ICC\/IF, IHC-P, WB in human, mouse samples.\u003cbr\u003e\nAnti-GATA3 antibody [EPR16651] - ChIP Grade (ab199428) has been cited over 65 times in peer reviewed journals and is trusted by the scientific community.\u003cbr\u003e\nAbcams high quality manufacturing and validation processes ensure Anti-GATA3 antibody [EPR16651] - ChIP Grade (ab199428) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility.\u003cbr\u003e\nThe specificity of Anti-GATA3 antibody [EPR16651] - ChIP Grade (ab199428) has been confirmed by testing in knockout samples.\u003cbr\u003e\nAnti-GATA3 antibody [EPR16651] - ChIP Grade (ab199428) has 12 independent reviews from customers.\u003cbr\u003e\nAnti-GATA3 antibody [EPR16651] - ChIP Grade (ab199428) specifically detects GATA3 (UniProt ID: P23771; Molecular weight: 48kDa) and is sold in 100 uL and 1 mL selling sizes.\u003cbr\u003e\nConjugation-ready, carrier free format available for antibody clone EPR16651 -\u003cbr\u003e\nab21484\u003cbr\u003e\nAntibody clone EPR16651 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 488, Alexa Fluor® 647, Alexa Fluor® 555, PE (\u003cbr\u003e\nab28895\u003cbr\u003e\nab28896\u003cbr\u003e\nab21672\u003cbr\u003e\nab225419\u003cbr\u003e\nGATA3 is crucial for T-cell development and differentiation, and its dysregulation is linked to diseases like breast cancer, T-cell lymphomas, and autoimmune disorders.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGATA3 also known as GATA-binding factor 3 is a transcription factor with a molecular mass of about 50 kDa. It belongs to the GATA family of zinc finger transcription factors. GATA3 is mainly expressed in the immune system especially in T-cells as well as in the nervous system and mammary glands. It plays a role in the regulation of critical developmental processes and cell lineage commitment through its binding to the 'GATA' motif in the promoter regions of target genes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGATA3 functions as a regulator of gene expression involved in various differentiation processes. It is not a solitary molecule; it interacts with other proteins to form transcriptional complexes. In T-helper type 2 (Th2) cells GATA3 is necessary for Th2 cell differentiation and cytokine production. Its expression is vital for the development of the nervous system and mammary gland morphogenesis highlighting its role in diverse biological contexts.\u003cbr\u003e\nPathways\u003cbr\u003e\nGATA3 plays a significant role in the Th2 differentiation pathway and is linked to the immune response. It acts in association with other transcription factors like STAT6 and T-bet. GATA3 promotes the transcription of Th2 cytokines such as IL-4 IL-5 and IL-13 while suppressing Th1 responses. This balance orchestrated by GATA3 is important for immune homeostasis and the body's ability to respond to infections and allergens.\u003cbr\u003e\nThe dysregulation of GATA3 is associated with atopic diseases and breast cancer. Aberrant expression of GATA3 is often observed in allergic conditions due to its role in Th2 cell differentiation and cytokine expression. In the context of breast cancer GATA3 levels can impact tumor progression and are correlated with estrogen receptor status. Additionally its relation with other breast cancer-related proteins like L50 underlines its importance in cancer biology and potential as a therapeutic target.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844032123049,"sku":"ab199428","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab199428","provider":"Iright","version":"1.0","type":"link"}