{"product_id":"abcam-ab199481","title":"Abcam, ab199481, Anti-Pan-Farnesylation antibody [EPR19409]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal Pan-Farnesylation antibody. Suitable for Dot, WB and reacts with Synthetic peptide, Human samples. Cited in 3 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR19409,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Dot, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:The antibody was developed specifically for farnesylated LKB1. Refer to the literature (PMID: 24295069), it might also interact with other farnesylated proteins.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPan-farnesylation refers to a post-translational modification where a farnesyl group attaches to proteins allowing them to anchor to cellular membranes. This process involves farnesylated proteins which include small GTPases like Ras Rho and nuclear lamins. The farnesyl group derived from farnesyl diphosphate is a 15-carbon isoprenoid lipid precursor. Farnesylation occurs in eukaryotic cells and is mediated by farnesyltransferase which recognizes the CaaX motif on the target protein. This modification happens mostly in the cytoplasm and enables proteins to associate with the inner nuclear membrane and the membrane of the endoplasmic reticulum.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis lipid modification facilitates protein-protein interactions and membrane localization required for signal transduction and cell cycle regulation. Farnesylation is essential for the function of many proteins but does not happen as part of a complex. It plays a role in the structural integrity and function of the cell by helping to establish protein orientation and interaction networks at the membrane surface. Farnesylated proteins like Ras participate in transmitting signals from extracellular receptors to intracellular targets which influence cell proliferation and differentiation.\u003cbr\u003e\nPathways\u003cbr\u003e\nFarnesylation is a critical step in the post-translational modification pathways enabling proper localization and activation of signaling molecules. It is heavily implicated in the Ras-MAPK signaling pathway where farnesylated Ras proteins take part in cellular responses to growth factors. Different members of the Ras family undergo this modification influencing downstream signaling pathways like ERK. Additionally the farnesylation of nuclear lamins integrates into pathways concerning nuclear envelope organization and integrity essential for maintaining cellular architecture.\u003cbr\u003e\nImpaired farnesylation processes can lead to pathologies such as cancer and progeria. Farnesylation of Ras proteins links to oncogenesis as mutations in ras genes result in constitutively active farnesylated Ras promoting uncontrolled cell division in many cancers. In Hutchinson-Gilford progeria syndrome lack of proper lamin A farnesylation affects nuclear structure leading to premature aging. These connections highlight the significance of farnesylation in maintaining normal cellular function and how its dysregulation can contribute to severe diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850458747049,"sku":"ab199481","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab199481","provider":"Iright","version":"1.0","type":"link"}