{"product_id":"abcam-ab199729","title":"Abcam, ab199729, Anti-MIOX antibody [EPR17172]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal MIOX antibody. Suitable for IP, WB and reacts with Mouse, Human samples. Cited in 3 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR17172,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe protein MIOX also known as myo-inositol oxygenase plays an important role in the conversion of myo-inositol into D-glucuronic acid. This metabolic enzyme has a mass of about 33 kDa. It is expressed mainly in the kidney particularly in the proximal tubules. MIOX functions as a monomer and contains a non-heme iron at its active site which is essential for its enzymatic activity.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMIOX is involved in myo-inositol metabolism an important process for maintaining cellular osmolyte balance and signaling. It does not form part of a larger protein complex. Myo-inositol metabolism impacts various cellular functions including phosphoinositide synthesis which is important for cellular signaling pathways. MIOX by controlling myo-inositol levels therefore influences these cellular processes that are critical for kidney function.\u003cbr\u003e\nPathways\u003cbr\u003e\nMIOX is a part of the inositol phosphate metabolism pathway. This pathway is critical for glucose and lipid metabolism affecting energy balance and cellular homeostasis. Additionally MIOX interacts with proteins involved in glucose metabolism such as enzymes in the glycolytic pathway highlighting its role in energy production and regulation. These interactions showcase MIOX's integration in broader metabolic networks.\u003cbr\u003e\nAbnormal MIOX activity links to conditions such as diabetic nephropathy and kidney injury. MIOX overexpression has been observed in diabetic nephropathy where it might contribute to oxidative stress and kidney damage. Additionally altered MIOX activity associates with proteins like SOD1 which is implicated in oxidative stress responses. Understanding MIOX's involvement offers potential therapeutic insights for managing related renal disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850289238185,"sku":"ab199729","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab199729","provider":"Iright","version":"1.0","type":"link"}