{"product_id":"abcam-ab200204","title":"Abcam, ab200204, Anti-FXYD1\/PLM antibody [EPR16082]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal FXYD1\/PLM antibody. Suitable for IP, WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR16082,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nFXYD1 also known as phospholemman (PLM) is a small transmembrane protein with a molecular mass of approximately 15 kDa. It is expressed mainly in cardiac and skeletal muscles where it plays a mechanical role in regulating ion transport across cell membranes. This protein modulates the activity of the Na+\/K+-ATPase pump influencing the transport of sodium and potassium ions which is important for maintaining cellular homeostasis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPhospholemman participates in the regulation of cardiac contractility and is involved in muscle relaxation processes. As a component of the Na+\/K+-ATPase pump complex it affects the pump's affinity for sodium ions which is important for its normal function. The effector actions of FXYD1 are modulated by phosphorylation allowing it to serve as an important regulator of cardiac output under varying physiological conditions.\u003cbr\u003e\nPathways\u003cbr\u003e\nPhospholemman features in the ion homeostasis and excitability pathway where its action on the Na+\/K+-ATPase pump links it to regulation of cardiac action potential. This regulation involves interaction with other membrane proteins like ankyrin which further connects FXYD1 to integrative cardiovascular mechanisms. Additionally FXYD1 impacts membrane hyperpolarization positioning it in the pathway that controls cell excitability and signal transduction in muscle tissues.\u003cbr\u003e\nDysregulation of FXYD1 is linked to heart failure and arrhythmias. Altered expression or function of this protein can affect Na+\/K+-ATPase efficiency leading to imbalanced ion transport and compromised cardiac function. Interaction with proteins such as cAMP-dependent protein kinase also implicates FXYD1 in various cardiac pathologies influencing the therapeutic targeting of this protein in cardiovascular diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850353987753,"sku":"ab200204","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab200204","provider":"Iright","version":"1.0","type":"link"}