{"product_id":"abcam-ab200236","title":"Abcam, ab200236, Recombinant human EREG protein","description":"\u003cp\u003eSize: 5µg\u003cbr\u003e\nRecombinant human EREG protein is a Human Fragment protein, in the 60 to 108 aa range, expressed in Escherichia coli, with \u0026gt;95%, \u0026lt; 1 EU\/µg endotoxin level, suitable for SDS-PAGE, FuncS, HPLC.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;95% SDS-PAGE,\u003cbr\u003e\nEndotoxin level:\u0026lt; 1 EU\/µg,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:Tag free,\u003cbr\u003e\nApplications:HPLC, SDS-PAGE, FuncSSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:Yes,\u003cbr\u003e\nBiological activity:The ED50 was determined by the dose-dependent stimulation of the proliferation of murine Balb\/3T3 cells is ≤ 2.0 ng\/mL, corresponding to a specific activity of ≥ 5 x 105 units\/mg.,\u003cbr\u003e\nAccession:O14944,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nReconstitution:Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg\/mL.,\u003cbr\u003e\nStorage buffer:pH: 7.4Constituents: 99% Phosphate Buffer, 0.75% Sodium chloride\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon reconstitution add a carrier protein (0.1% BSA), Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe EREG protein also known as epiregulin is part of the epidermal growth factor (EGF) family. It is a small polypeptide with a molecular weight of approximately 19 kDa. EREG is expressed in various tissues including the liver kidney and colon. It interacts with EGF receptors (EGFR) activating them through dimerization which then triggers downstream signaling processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nEpiregulin plays a significant role in cell proliferation migration and differentiation. It is not part of a larger complex but functions by binding to EGFR to exert its effects. Its interaction with EGFR influences numerous cellular processes important for tissue repair and development making EREG an important player in physiological and pathological conditions.\u003cbr\u003e\nPathways\u003cbr\u003e\nEpiregulin is tied into the EGFR signaling pathway and the MAPK pathway. It works together with other growth factors like transforming growth factor-alpha (TGF-α) in these pathways. Through EGFR activation EREG influences cellular responses that are critical for growth and survival linking it to broader biological functions involving MAPK signaling cascades.\u003cbr\u003e\nEpiregulin links to cancer progression and inflammatory diseases. In some cancers EREG overexpression correlates with aggressive tumor growth and poor prognosis. In inflammatory conditions it can modulate responses impacting diseases such as psoriasis by interacting with proteins like EGFR. Understanding EREG's roles provides insights into therapeutic strategies targeting EGFR-related pathways.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844016525481,"sku":"ab200236","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab200236","provider":"Iright","version":"1.0","type":"link"}