{"product_id":"abcam-ab202058","title":"Abcam, ab202058, Anti-PMM1 antibody [EPR17844]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal PMM1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat, Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR17844,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe protein Phosphomannomutase 1 (PMM1) plays an essential role in carbohydrate metabolism by catalyzing the interconversion of mannose-6-phosphate and mannose-1-phosphate. The protein is also known as PMM-1 and has a molecular weight of approximately 28 kDa. PMM1 is expressed in various tissues including the liver kidney and muscle indicating its wide physiological relevance. Its enzymatic function is important for producing GDP-mannose which is necessary for glycosylation processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPMM1 facilitates the conversion of mannose phosphates which is important in protein glycosylation pathways particularly in the synthesis of N-linked glycoproteins. PMM1 operates as a monomer and it does not form part of any larger enzymatic complex. Its activity ensures a proper supply of mannose-1-phosphate required for synthesizing GDP-mannose a donor substrate for glycosylation reactions that is critical in the production of structural molecules and signaling pathways.\u003cbr\u003e\nPathways\u003cbr\u003e\nPMM1 plays a significant role in the biosynthesis of GDP-mannose and impacts the N-glycosylation pathway. PMM1's enzymatic activities integrate closely with glycosylation pathways interfacing with proteins involved in glycan assembly and modification. It interacts with other metabolic pathways that involve mannose and cooperatively influences the cellular processes for protein targeting and function through glycosylation alongside proteins like phosphomannose isomerase (PMI).\u003cbr\u003e\nPMM1 mutations and dysregulation show potential links to congenital disorders of glycosylation (CDG). These disorders arise from improper glycosylation affecting a variety of bodily systems. PMM1's function and interaction with other glycosylating proteins such as PMM2 is critical in addressing the potential glycosylation defects that contribute to these rare genetic disorders. Although detailed studies are ongoing PMM1 remains a vital focus in understanding the molecular basis of these diseases and potentially developing therapeutic interventions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850327543977,"sku":"ab202058","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab202058","provider":"Iright","version":"1.0","type":"link"}