{"product_id":"abcam-ab203206","title":"Abcam, ab203206, Anti-NFAM1 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal NFAM1 antibody. Suitable for IHC-P, Flow Cyt and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human NFAM1 aa 100-150 conjugated to Keyhole Limpet Haemocyanin.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:IHC-P, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human NFAM1 aa 100-150 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q8NET5\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Proclin 300Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNFAM1 also known as NFAT activating protein with an undefined function 1 is a protein expressed on the surface of immune cells such as B cells and T cells. It consists of approximately 46 kDa. This membrane-associated protein plays a significant role in the activation of nuclear factor of activated T-cells (NFAT) a family of transcription factors integral to immune responses. Researchers originally identified NFAM1 in immune system cells pointing to its immunological relevance.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe role of NFAM1 involves important signal transduction processes that support immune cell activation and function. NFAM1 likely participates in complex interactions on the cell surface that facilitate NFAT activation although the specific molecular interactions remain under investigation. Evidence suggests that it may integrate signals from various receptors orchestrating immune cell responses and contributing to the adaptive immune system.\u003cbr\u003e\nPathways\u003cbr\u003e\nNFAM1 is notably involved in the NFAT signaling pathway which regulates gene expression essential for immune cell function. This protein interacts closely with other molecules in the pathway including calcineurin a phosphatase critical for NFAT dephosphorylation. Such interactions reinforce NFAM1's role in maintaining effective immune responses. Additionally NFAM1 has a role in the broader context of the T-cell receptor signaling pathway further highlighting its importance in immune regulation.\u003cbr\u003e\nNFAM1's involvement in autoimmune conditions and certain immunodeficiencies stands out. Researchers have linked dysregulation of NFAT signaling where NFAM1 is active to autoimmune diseases such as rheumatoid arthritis. Furthermore improper NFAM1 function may affect T cell-mediated immune responses contributing to specific immunodeficiency disorders. Investigating NFAM1's interactions with proteins such as NFATc1 and its impact on disease progression offers potential avenues for understanding and treating these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860694683817,"sku":"ab203206","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab203206","provider":"Iright","version":"1.0","type":"link"}