{"product_id":"abcam-ab203345","title":"Abcam, ab203345, Anti-WDR26 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal WDR26 antibody. Suitable for IHC-P and reacts with Rat, Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human WDR26 aa 250-350 conjugated to Keyhole Limpet Haemocyanin.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Rat, Human,\u003cbr\u003e\nApplications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human WDR26 aa 250-350 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q9H7D7\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Proclin 300Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nWDR26 also known as WD repeat domain 26 is part of the WD repeat protein family which is important in protein-protein interactions. It weighs roughly 109 kDa. WDR26 expresses in various tissues with significant levels observed in the brain and testis. The protein itself has a molecular architecture enriched with WD repeats which facilitates its involvement in cellular processes by mediating complex formation and signal transduction.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nIn the cellular environment WDR26 engages in regulating intracellular signaling pathways. It is a component of the STRIPAK complex which includes several proteins playing roles in synaptic and cellular signaling. The involvement of WDR26 in the STRIPAK complex as a scaffold aids in the correct assembly and localization of the complex impacting cellular processes such as apoptosis and proliferation.\u003cbr\u003e\nPathways\u003cbr\u003e\nWDR26 integrates into key signaling pathways like the MAPK signaling pathway. It interacts with other proteins such as STRN3 and MOB3 to modulate signals that affect gene expression growth and cell differentiation. The MAPK pathway in particular facilitates responses to growth factors stress signals and mitogens illustrating the protein's versatility in signal transduction.\u003cbr\u003e\nDefects or dysregulation of WDR26 relate to intellectual disabilities and certain neurodevelopmental disorders. Research indicates that changes in WDR26 expression can disturb normal brain development and function often connecting with other proteins like MEK1 which also participates in neurodevelopment. These connections link WDR26 closely to neurological functions and highlight its potential as a target for therapeutic interventions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848614269097,"sku":"ab203345","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab203345","provider":"Iright","version":"1.0","type":"link"}