{"product_id":"abcam-ab203900","title":"Abcam, ab203900, Anti-NAGK antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal NAGK antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NAGK aa 1-100.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human NAGK aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q9UJ70\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nN-Acetylglucosamine Kinase (NAGK) also known as GlcNAc kinase catalyzes the phosphorylation of N-acetylglucosamine to N-acetylglucosamine-6-phosphate. It has a molecular mass of approximately 37 kDa. NAGK expresses in various tissues prominently within the liver and pancreas indicating its involvement in metabolic functions related to these organs.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNAGK plays a significant role in amino sugar and nucleotide sugar metabolism. It does not form part of a large protein complex but interacts with other metabolic enzymes to carry out its function. By converting N-acetylglucosamine to its phosphorylated form NAGK helps to maintain cellular energy balance and provides substrates necessary for glycosylation processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe enzymatic activity of NAGK is essential in the hexosamine biosynthetic pathway. This pathway feeds into glycosylation processes necessary for protein modification and cellular communication. NAGK activity links to proteins such as UDP-N-acetylglucosamine pyrophosphorylase in these pathways highlighting its role in maintaining cellular function and integrity.\u003cbr\u003e\nAlterations in NAGK function relate to metabolic syndromes and potential glycosylation disorders. Changes in NAGK could affect pathways involving N-linked glycosylation which plays a role in diseases like congenital disorders of glycosylation. Proteins such as glutamine fructose-6-phosphate amidotransferase may also interact with NAGK in the context of these diseases affecting broader metabolic processes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854355026089,"sku":"ab203900","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab203900","provider":"Iright","version":"1.0","type":"link"}