{"product_id":"abcam-ab204127","title":"Abcam, ab204127, Anti-MIM antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal MIM antibody. Suitable for WB and reacts with Mouse samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human MTSS1 aa 100-200 conjugated to Keyhole Limpet Haemocyanin.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human MTSS1 aa 100-200 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.O43312\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Proclin 300Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe target MIM also known as Missing in Metastasis or MTSS1 plays an important role in cellular structure and signaling mechanics. MIM a protein with an approximate mass of 72 kDa interacts with the actin cytoskeleton to facilitate the remodelling of cell shape and movement. This protein is largely expressed in tissues such as the prostate breast and bladder. Its presence shows reduction in metastatic cancer cells explaining its role in controlling cell adhesion and movement.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMissing in Metastasis functions in actin-binding processes and serves as an important player in cellular signal transduction mechanisms. MIM associates with other cellular components forming complexes that stabilize the actin cytoskeleton. It modulates the signaling pathways by interacting with proteins like Cortactin influencing cellular events such as migration and invasiveness. This protein's interactions strongly suggest a role in maintaining cellular integrity and suppressing metastatic behaviors.\u003cbr\u003e\nPathways\u003cbr\u003e\nResearchers link Missing in Metastasis to signaling pathways controlling cell growth and movement like the Wnt signaling pathway and actin polymerization. It collaborates closely with proteins like Profilin 1 and suppresses Wiskott-Aldrich Syndrome Protein (WASP) which play significant roles in these biological pathways. MIM’s involvement in these pathways underlines its function in balancing cellular dynamics and influencing cellular responses.\u003cbr\u003e\nStudies have extensively associated Missing in Metastasis with various cancers especially bladder and breast cancers. In these diseases MIM expression often correlates with suppressed metastasis highlighting a potential therapeutic angle. Additionally MIM interacts with oncogenic proteins such as ERBB2 in breast cancer identifying its role in tumor suppression pathways. Better understanding MIM’s relationships with these proteins and diseases suggests pathways for future therapeutic development.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848602701993,"sku":"ab204127","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab204127","provider":"Iright","version":"1.0","type":"link"}