{"product_id":"abcam-ab204178","title":"Abcam, ab204178, Anti-Reticulocalbin 3 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal Reticulocalbin 3 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RCN3 aa 150-300.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human RCN3 aa 150-300. The exact immunogen used to generate this antibody is proprietary information.Q96D15\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nReticulocalbin 3 also known as ERC-55 or RCN3 is a calcium-binding protein localized in the endoplasmic reticulum. It has a molecular mass of around 44 kDa. Reticulocalbin 3 is expressed in various tissues with strong expression in the heart liver and skeletal muscles. It binds calcium through its EF-hand domains which are responsible for its ability to interact with other calcium-dependent proteins and ions. This makes it an important component of maintaining calcium homeostasis within the endoplasmic reticulum.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nReticulocalbin 3 plays a role in calcium-dependent signaling processes that affect protein folding and secretion. It is part of a complex involved in glycoprotein maturation and quality control within the endoplasmic reticulum. Reticulocalbin 3 helps ensure proper protein folding which is essential for cellular function. By influencing endoplasmic reticulum stress responses Reticulocalbin 3 contributes to overall cellular health and functionality.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe role of Reticulocalbin 3 can be seen in the endoplasmic reticulum-associated degradation (ERAD) pathway and the unfolded protein response (UPR). These pathways help manage protein misfolding and cellular stress levels. Within these pathways Reticulocalbin 3 interacts with proteins like calreticulin and calnexin which are also involved in calcium binding and protein folding mechanisms. Its function supports the regulation and maintenance of protein quality control aiding in the survival of stressed cells.\u003cbr\u003e\nReticulocalbin 3 shows a connection with diseases involving improper protein folding such as cystic fibrosis and some forms of liver disease. For instance in cystic fibrosis defective protein folding affects the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Reticulocalbin 3 may interact with proteins such as BiP\/GRP78 involved in maintaining proper protein conformation. By stabilizing protein folding pathways Reticulocalbin 3 potentially influences the progression and severity of these conditions making it an interesting target for therapeutic intervention.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854133416105,"sku":"ab204178","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab204178","provider":"Iright","version":"1.0","type":"link"}