{"product_id":"abcam-ab20454","title":"Abcam, ab20454, Anti-FOXI1 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nGoat Polyclonal FOXI1 antibody. Suitable for ChIP, WB, IHC-P, IHC-Fr and reacts with Human samples. Cited in 18 publications. Immunogen corresponding to Synthetic Peptide within Human FOXI1 aa 350 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Goat,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, IHC-Fr, ChIP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human FOXI1 aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q12951,\u003cbr\u003e\nSpecificity:This antibody is expected to recognise both reported human isoforms.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Forkhead box I1 (FOXI1) also known by various alternative names such as HFH3 or FKHL10 is a transcription factor with a mass of approximately 40 kDa. It is predominantly expressed in epithelial tissues including the kidney and inner ear. FOXI1 plays a mechanical role by binding to specific DNA sequences to regulate the transcription of target genes influencing cellular development and differentiation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFOXI1 impacts several fundamental processes including the development of epithelial structures. It acts as a member of the forkhead family of transcription factors known for their roles in cellular growth and differentiation. FOXI1 does not typically form part of a larger protein complex but it interacts with other proteins such as FOXE1 and FGFR2 to execute its biological functions efficiently. These interactions are important for proper organ formation and function.\u003cbr\u003e\nPathways\u003cbr\u003e\nSeveral cellular and developmental pathways involve FOXI1. Notably FOXI1 plays an important role in the Wnt signaling pathway essential for cell fate determination and organ development. In this context FOXI1 regulates gene expression by interacting with other pathway components like β-catenin. Additionally FOXI1 participates in the hedgehog signaling pathway where its involvement influences gene transcription in response to developmental cues.\u003cbr\u003e\nMutations or dysregulation of FOXI1 have connections to conditions such as distal renal tubular acidosis and sensorineural hearing loss. In distal renal tubular acidosis FOXI1's transcriptional control affects ion channel and transporter expression in the kidney. The disorder links to other proteins like AE1 and H+-ATPase where altered FOXI1 activity influences their expression or function. Sensorineural hearing loss associations with FOXI1 involve its regulatory roles in the inner ear's development affecting auditory function.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845039411369,"sku":"ab20454","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab20454","provider":"Iright","version":"1.0","type":"link"}