{"product_id":"abcam-ab204553","title":"Abcam, ab204553, Anti-CPVL antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal CPVL antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CPVL aa 250-350.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human CPVL aa 250-350. The exact immunogen used to generate this antibody is proprietary information.Q9H3G5\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCPVL stands for Carboxypeptidase Vitellogenic-Like and it functions as a serine carboxypeptidase involved in protein degradation processes. Also known by the name serine carboxypeptidase vitellogenic-like CPVL has a molecular mass of approximately 54 kDa. It is expressed mainly in macrophages and monocytes which are important components in the body's immune system. The enzyme plays a role in breaking down cellular proteins as part of normal cellular maintenance and defense mechanisms.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCPVL contributes to the catabolism of proteins within immune cells aiding in the removal of peptides generated from cellular turnover and antigen processing. As part of the larger molecular complex of proteasomes and other proteolytic systems it participates in maintaining intracellular protein homeostasis. CPVL's activity supports the immune response by processing phosphoproteins and contributing to antigen presentation therefore influencing immune surveillance and response to pathogens.\u003cbr\u003e\nPathways\u003cbr\u003e\nCPVL functions in key biological routes such as protein degradation and immune system regulation processes. Within these pathways CPVL interacts with other peptidases and proteolytic enzymes including the ubiquitin-proteasome system. This interaction highlights its role in managing protein quality control and influencing processes related to inflammation pathways. CPVL might work alongside other proteases like cathepsin L in these pathways emphasizing their coordinated roles in protein catabolism.\u003cbr\u003e\nCPVL has connections to inflammatory diseases such as atherosclerosis and certain autoimmune conditions. Abnormal expression or mutation of CPVL could lead to altered macrophage function contributing to these conditions' pathogenesis. The protein also interacts in disease contexts with factors like interleukin-6 a cytokine implicated in inflammatory responses. These links suggest CPVL's importance in understanding inflammatory disease mechanisms and potential therapeutic strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854229983401,"sku":"ab204553","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab204553","provider":"Iright","version":"1.0","type":"link"}