{"product_id":"abcam-ab206655","title":"Abcam, ab206655, Anti-CYP27B1 antibody [EPR20271]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal CYP27B1 antibody. Suitable for IP, WB, IHC-P and reacts with Human, Mouse, Rat, Recombinant fragment samples. Cited in 21 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR20271,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Rat, Human, Mouse,\u003cbr\u003e\nApplications:IP, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCytochrome P450 family 27 subfamily B member 1 (CYP27B1) also known as 25-hydroxyvitamin D3 1-alpha-hydroxylase plays a mechanical role in the hydroxylation of 25-hydroxyvitamin D3 into the active form 125-dihydroxyvitamin D3 (calcitriol). This enzyme is approximately 56 kDa in size. Expression is notably high in the kidneys which is the primary site for its enzymatic activity but it is also present in several other tissues including skin lungs and immune cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe active form of vitamin D produced by CYP27B1 is essential for maintaining mineral homeostasis and bone health. The enzyme is not traditionally part of a larger protein complex but works closely with vitamin D binding proteins to interact with its substrates. The active vitamin D influences calcium and phosphate balance in the body which has implications for overall bone integrity and immune system regulation.\u003cbr\u003e\nPathways\u003cbr\u003e\nCYP27B1 plays a significant role in the vitamin D metabolic pathway and the calcium signaling pathway. It functions upstream of the vitamin D receptor (VDR) that helps control calcium absorption in the gut. CYP24A1 another related cytochrome P450 enzyme participates in degrading the active form of vitamin D maintaining an important balance within the system. Together these pathways and proteins help regulate calcium levels critical to many physiological processes.\u003cbr\u003e\nCYP27B1 has notable connections to rickets and osteoporosis. Mutations in the CYP27B1 gene can lead to reduced or absent enzyme activity resulting in Vitamin D-dependent rickets type 1 characterized by impaired bone mineralization. Its activity also affects osteoporosis a condition of reduced bone density. The balance between CYP27B1 and CYP24A1 is important in understanding the pathogenesis of these bone-related disorders where altered vitamin D metabolism can contribute to disease development.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844161949865,"sku":"ab206655","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab206655","provider":"Iright","version":"1.0","type":"link"}