{"product_id":"abcam-ab206776","title":"Abcam, ab206776, Anti-beta Arrestin 1 antibody [E274] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal beta Arrestin 1 antibody. Carrier free. Suitable for IHC-P, WB, ICC\/IF, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples. Cited in 8 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:E274,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WB, ICC\/IF, Flow Cyt (Intra), IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:The antibody immunogen shares 90% homology with ARRB2 (P32121) which has similar MW than ARRB1. Therefore, it is likely that the antbody will cross-react with ARRB2. However, we haven't performed any experiment with recombinant protein to confirm this.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab206776 is the carrier-free version of\u003cbr\u003e\nab32099\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nBeta Arrestin 1 also known as β-arrestin b-arrestin or ARRB1 is a protein that plays an important role in cell signaling mechanisms. It has a molecular mass of approximately 47 kDa and is expressed in various tissues with high expression levels in the brain and testes. Beta Arrestin 1 binds to G protein-coupled receptors (GPCRs) leading to the termination of coupling between the GPCRs and G proteins. This function is essential in regulating the receptor's signal and mediating receptor desensitization.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nBeta Arrestin 1 functions beyond GPCR desensitization by participating in receptor internalization and the initiation of alternative signaling pathways known as arrestin-mediated signaling. It acts as part of a greater complex with clathrin and adaptin which facilitates the endocytosis of GPCRs. In doing so beta Arrestin 1 can modulate different signaling pathways independently of G proteins influencing various cellular responses.\u003cbr\u003e\nPathways\u003cbr\u003e\nBeta Arrestin 1 integrates into the MAPK\/ERK pathway and the PI3K\/AKT pathway. These pathways are important for regulating diverse cellular processes including proliferation differentiation and survival. Through the MAPK\/ERK pathway beta Arrestin 1 is connected to proteins such as extracellular signal-regulated kinases (ERK1\/2). In the context of the PI3K\/AKT pathway it associates with phosphoinositide 3-kinase helping to control cell growth and survival mechanisms.\u003cbr\u003e\nDisruptions involving beta Arrestin 1 have implications in cancer and cardiovascular diseases. In cancer abnormal beta Arrestin 1 activity can influence tumor growth by altering cell proliferation and survival signaling pathways. It links to proteins like ERK1\/2 and PI3K which can drive oncogenic processes. In cardiovascular disorders beta Arrestin 1 is implicated in heart failure where its altered activity affects cardiovascular signaling pathways influencing heart function and response to stress.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851598778537,"sku":"ab206776","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab206776","provider":"Iright","version":"1.0","type":"link"}