{"product_id":"abcam-ab2071","title":"Abcam, ab2071, Anti-STAT1 alpha antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal STAT1 antibody. Suitable for WB, IHC-P, ICC\/IF and reacts with Mouse, Rat, Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human STAT1 aa 700 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IHC-P, WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human STAT1 aa 700 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P42224\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azide, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSTAT1 alpha also known as Signal Transducer and Activator of Transcription 1-alpha is a protein with a mass of approximately 91 kDa. It operates in the cell nucleus and cytoplasm to mediate signal transduction and activation of transcription. STAT1 alpha does this by dimerizing following phosphorylation enabling its nuclear translocation. It is broadly expressed in many tissues including immune cells. This expression plays an important role in response to cytokines and other signaling molecules.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSTAT1 alpha functions as a critical component of the interferon signaling pathway. It is part of a transcription factor complex that regulates the expression of genes involved in cell proliferation differentiation and immune response. STAT1 alpha mediates its effects by forming homo- or heterodimers with related proteins and binding to specific DNA sequences. This interaction facilitates the transcription of genes necessary for innate and adaptive immunity highlighting its fundamental role in host defense mechanisms.\u003cbr\u003e\nPathways\u003cbr\u003e\nSTAT1 alpha participates in the JAK-STAT signaling pathway and interferon signaling pathways. It interacts with Janus kinases (JAKs) after cytokine stimulation resulting in its phosphorylation and dimerization. This pathway links it with other STAT family members such as STAT2 and STAT3 to regulate gene expression. These pathways ensure proper immune function and cell growth control indicating STAT1 alpha's essential role in various cellular processes.\u003cbr\u003e\nSTAT1 alpha is associated with autoimmune diseases and certain cancers. Its malfunction can result in inadequate immune responses or excessive inflammation. In some cancers altered STAT1 alpha activity contributes to unchecked cell proliferation. STAT1 alpha interacts with various proteins such as IFNGR1 and IRF1 in these disease states affecting their signaling pathways. Its dysregulation indicates a potential target for therapeutic intervention in these disorders making it of interest for medical research.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854127157417,"sku":"ab2071","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab2071","provider":"Iright","version":"1.0","type":"link"}