{"product_id":"abcam-ab207386","title":"Abcam, ab207386, Alexa Fluor® 647 Anti-MAT2A + MAT1A antibody [EPR10496]","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Recombinant Monoclonal MAT1A antibody - conjugated to Alexa Fluor® 647. Suitable for ICC\/IF and reacts with Human samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR10496,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nConjugation:Alexa Fluor® 647,\u003cbr\u003e\nExcitation\/Emission:Ex: 650nm, Em: 665nm,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nAlexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle, Stable for 12 months at -20°C, Store in the dark\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMAT2A (Methionine Adenosyltransferase 2A) and MAT1A (Methionine Adenosyltransferase 1A) are enzymes that catalyze the formation of S-adenosylmethionine (SAM) from methionine and ATP. MAT2A also known as hepatic MAT has a mass of approximately 52 kDa while MAT1A also sometimes referred to as extrahepatic MAT typically weighs around 48 kDa. Both enzymes differ in their tissue expression: MAT1A is predominantly found in the liver whereas MAT2A expresses across various tissues such as the brain and intestines.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMAT2A and MAT1A are key in the methionine cycle impacting gene regulation through methylation reactions. They facilitate the synthesis of SAM a universal methyl donor essential for transmethylation processes within cells. Specifically MAT1A forms a complex with glycine N-methyltransferase to regulate homocysteine and methylation homeostasis. Both enzymes perform a role in controlling the abundance of SAM which influences various cellular processes including nucleic acid protein and lipid metabolism.\u003cbr\u003e\nPathways\u003cbr\u003e\nMAT2A and MAT1A participate actively in methionine and SAM metabolism. They integrate within the one-carbon metabolism pathway which is critical for methylation processes affecting gene expression and epigenetic regulation. MAT2A interacts with proteins like MAT2B which modulates the activity of MAT2A impacting the balance between SAM and S-adenosylhomocysteine. This pathway interaction is important for maintaining methylation balance and cellular proliferation.\u003cbr\u003e\nMAT2A and MAT1A relate to liver diseases and cancer reflecting their roles in SAM metabolism. Abnormal function or expression of these enzymes affects SAM levels linking to liver cirrhosis and hepatocellular carcinoma. MAT1A mutations can impair methionine metabolism exacerbating liver conditions. Similarly altered MAT2A expression associates with certain cancers where it modulates cellular methylation states and growth. Proteins like SAM might get affected creating an imbalance that contributes to the pathology of liver disease and oncogenesis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852619108521,"sku":"ab207386","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab207386","provider":"Iright","version":"1.0","type":"link"}