{"product_id":"abcam-ab207718","title":"Abcam, ab207718, Anti-CEACAM5 + CD66b + CEACAM1 + CEACAM6 antibody [EPR20721]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal CEACAM5 antibody. Suitable for Flow Cyt, WB, ICC\/IF, IHC-P and reacts with Human, Transfected cell line - Human samples. Cited in 12 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR20721,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IF, Flow Cyt, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:ab207718 cross-reacts with CEACAM 1, 6 and 8. There are other CEACAM family members but we only examined cross-reactivity with those having \u0026gt;55% homology with CEACAM5 following a BLAST search with the immunogen.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCEACAM5 also known as CEA or CD66e is part of the carcinoembryonic antigen family. It plays a role as a cell adhesion molecule facilitating intercellular binding. CEACAM5 is a glycoprotein with a molecular mass of approximately 180 kDa. You find CEACAM5 expression in normal epithelial tissues such as the colon stomach and tongue but it shows increased levels in various carcinoma cells. It is also identified as CEACAM6 and both of these linked proteins function as cell surface glycoproteins involved in cellular interactions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCEACAM5 proteins influence cell signaling and intercellular communication. They participate in immune response modulation and function as part of larger protein complexes. CEACAM5 acts as an anchor point for various cellular processes by associating with CEACAM1 and CEACAM6. By regulating cell adhesion CEACAM5 helps in maintaining normal cellular architecture and function within tissue environments.\u003cbr\u003e\nPathways\u003cbr\u003e\nCEACAM5 is integral to pathways involving cell adhesion and signaling. It participates in immune system responses and the regulation of cell proliferation pathways including the MEK\/ERK signaling cascade. CEACAM5 proteins interact with others like CEACAM1 sharing roles in cell signaling and communication networks that control adhesion dynamics and growth factor responses.\u003cbr\u003e\nExcessive CEACAM5 expression links to colorectal and gastric cancers making it a useful cancer biomarker. CEACAM5-positive tumors often correlate with disease progression which highlights their potential as therapeutic targets. These proteins also interact with CD66b markers which are associated with neutrophil activation in inflammatory responses. Such associations with CEACAM1 and CEACAM6 in carcinogenic pathways further underline CEACAM5's relevance in cancer diagnostics and treatment strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855863271593,"sku":"ab207718","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab207718","provider":"Iright","version":"1.0","type":"link"}