{"product_id":"abcam-ab209064","title":"Abcam, ab209064, Anti-TMEM119 antibody [28-3] - Microglial marker","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nAnti-TMEM119 antibody [28-3] - Microglial marker (ab209064) is a rabbit monoclonal antibody detecting TMEM119 in  IHC-P, IHC-Fr . Suitable for  Mouse . - KO validated for confirmed specificity - Biophysical QC for unrivalled batch-batch consistency - Over 130 publications\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:28-3,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse,\u003cbr\u003e\nApplications:IHC-Fr, IHC-P, IHC-FoFrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:This antibody recognizes mouse Tmem119, a transmembrane protein that has been reported to be a highly specific microglia marker that is not expressed by macrophages or other immune or neural cell types (Bennett et al., 2016).FURTHER INFORMATION ON SPECIFICITY (Chinese Version) available under the product protocols section. This file includes key technical notes of experience when using this product.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nAnti-TMEM119 antibody [28-3] - Microglial marker (ab209064) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in IHC-FoFr, IHC-Fr and IHC-P\u003cbr\u003e\nAnti-TMEM119 antibody [28-3] - Microglial marker (ab209064) was first used in a scientific publication in 2016 and has been cited over 139 times in peer reviewed journals. It's performance in IHC and Immunofluorescence in mouse samples is trusted by the scientific community.\u003cbr\u003e\nAbcam's high quality manufacturing and validation processes ensure Anti-TMEM119 antibody [28-3] - Microglial marker (ab209064) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility.\u003cbr\u003e\nThe specificity of Anti-TMEM119 antibody [28-3] - Microglial marker (ab209064) has been confirmed by IHC testing in TMEM119 knockout Mouse brain cells.\u003cbr\u003e\nAnti-TMEM119 antibody [28-3] - Microglial marker (ab209064) has 20 independent reviews from customers.\u003cbr\u003e\nAnti-TMEM119 antibody [28-3] - Microglial marker (ab209064) specifically detects TMEM119 (UniProt ID: Q4V9L6; Molecular weight: 27kDa) and is sold in a convenient trial size to enable initial testing (10 µL) and larger sizes for subsequent scaling up experiments (100 µL and 1 mL).\u003cbr\u003e\nConjugation-ready, carrier free format available for antibody clone 28-3 -\u003cbr\u003e\nab234501\u003cbr\u003e\nTMEM119 is a marker for microglia, the resident immune cells of the brain. In Alzheimer's disease (AD) research, TMEM119 is used to differentiate microglia from other brain-resident cells and infiltrating macrophages. Altered TMEM119 expression in AD brains reflects microglial activation and neuroinflammation, making it a valuable tool for studying the immune response and pathology in Alzheimer's disease.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 6.97% L-Arginine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTMEM119 also known as transmembrane protein 119 plays a role in cell membrane dynamics. It has a molecular mass of approximately 35 kDa. TMEM119 is specifically expressed in microglia in the central nervous system. Microglia serve essential functions in brain homeostasis and immune response. Given its expression profile TMEM119 serves as a marker to identify microglia especially in research focused on neurological tissues. Researchers often utilize techniques like microglial flow cytometry and microglial staining for identification and quantification of microglial populations often in frozen marker studies.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTMEM119 regulates signaling pathways that maintain microglial identity and function but does not typically form part of larger complexes. It modulates microglial activation states and influences responses to central nervous system injury and inflammation. As a membrane protein it may interact with other surface molecules although specific binding partners are not well-characterized in current literature. Researchers value TMEM119 as a reliable marker in studies aiming to distinguish brain-resident microglia from infiltrating peripheral macrophages.\u003cbr\u003e\nPathways\u003cbr\u003e\nTMEM119 functions as a modulator within inflammatory and neuroimmune pathways. It plays roles in the NF-κB signaling and the neuroinflammatory cascade. Its relationship with proteins like CD68 and Iba1 indicates it may influence pathways tied to immune responses and phagocytosis within nervous system contexts. Understanding the interactions and co-expression of TMEM119 with these proteins helps clarify its contribution to neuroimmune functions.\u003cbr\u003e\nTMEM119 links with neurological conditions such as Alzheimer's disease and multiple sclerosis. Altered expression of TMEM119 appears in disease states potentially contributing to pathogenesis through disrupted inflammatory responses. Its association with proteins such as TREM2 in Alzheimer's suggests that TMEM119 may play indirect roles in the progression of neurodegeneration. Furthermore high TMEM119 levels in pathological samples provide insights into microglial involvement in disease progression and potential targets for therapeutic interventions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844042510505,"sku":"ab209064","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab209064","provider":"Iright","version":"1.0","type":"link"}