{"product_id":"abcam-ab212436","title":"Abcam, ab212436, Anti-HLA B antibody [JOAN-1] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nMouse Monoclonal HLA B antibody. Carrier free. Suitable for Flow Cyt, ICC\/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Cell preparation containing HLA-B protein.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:JOAN-1,\u003cbr\u003e\nIsotype:IgG3,\u003cbr\u003e\nLight chain type:kappa,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Cell preparation containing HLA-B protein. The exact immunogen used to generate this antibody is proprietary information.P01889\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A\/G, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHLA-B also known as human leukocyte antigen B or HLA-B27 is a protein found in humans that plays a vital role in the immune system. As a type of major histocompatibility complex (MHC) class I molecule HLA-B displays peptide fragments from pathogens on the cell surface alerting cytotoxic T cells. HLA-B has a mass of approximately 45 kDa and is expressed on the surface of almost all nucleated cells including cells in the circulatory and lymphatic systems.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHLA-B molecules are essential for immune response regulation. They form part of a complex with β2-microglobulin which stabilizes the MHC class I molecule on the cell surface. This complex presents endogenous peptides sourced from intracellular proteins to the T-cell receptor (TCR) of CD8+ T cells. This recognition prompts T cell-mediated cytotoxicity a critical response for the elimination of infected or malignant cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nHLA-B functions within important immune response pathways including the antigen processing and presentation pathway. It works closely with other MHC class I molecules as well as the transporter associated with antigen processing (TAP) proteins that load peptides onto HLA-B for presentation. The pathway also involves proteasomes that generate peptide precursors required for MHC class I molecule loading highlighting HLA-B’s role in the broader immunological framework.\u003cbr\u003e\nHLA-B is notably associated with ankylosing spondylitis and certain types of reactive arthritis. Research shows a strong correlation between HLA-B27 a subtype of HLA-B and these autoimmune diseases indicating a possible role in their pathogenesis. Additionally variations in HLA-B expression and compatibility are significant in tissue transplantation where mismatches can result in transplant rejection involving related proteins such as other HLA molecules and T cell receptors.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855516127401,"sku":"ab212436","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab212436","provider":"Iright","version":"1.0","type":"link"}