{"product_id":"abcam-ab21288","title":"Abcam, ab21288, Anti-ECSIT antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal ECSIT antibody. Suitable for IP, WB, IHC-P, ICC\/IF and reacts with Mouse, Human samples. Cited in 12 publications. Immunogen corresponding to Synthetic Peptide within Human ECSIT.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Mouse,\u003cbr\u003e\nApplications:IP, ICC\/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human ECSIT. The exact immunogen used to generate this antibody is proprietary information.Q9BQ95\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Purification notes-Ion exchange chromatography., Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nECSIT also known as Evolutionarily Conserved Signaling Intermediate in Toll pathways is a mitochondrial protein involved in various cellular processes. It has a molecular mass of approximately 52 kDa and is prominently expressed in tissues with high metabolic activity such as the heart and skeletal muscles. ECSIT interacts with the mitochondrial membrane and is integral for mitochondrial function and biogenesis. Understanding the expression and function of ECSIT can provide insight into its role in cellular energy homeostasis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nECSIT influences several important cellular processes through its participation in the assembly of the mitochondrial complex I. It is part of a protein complex that includes NDUFAF1 and acts as a scaffold protein facilitating the proper assembly of complex I. ECSIT involvement is important for the maintenance of cellular respiration and energy production. Its role in complex I assembly highlights its importance in regulating mitochondrial activity and function.\u003cbr\u003e\nPathways\u003cbr\u003e\nECSIT acts in both mitochondrial biogenesis and the toll-like receptor (TLR) signaling pathway. In the TLR pathway ECSIT mediates interactions between TRAF6 and TAK1 contributing to the regulation of immune responses. It is an essential component linking mitochondrial function with immune signaling demonstrating its multi-functional capability. These pathways highlight the intricate network where ECSIT collaborates with proteins like TRAF6 and TAK1 to ensure proper immune response and energy metabolism.\u003cbr\u003e\nECSIT has associations with leigh syndrome and aggressive lung cancer. Its dysfunction in mitochondrial biogenesis can contribute to Leigh syndrome a severe neurological disorder. In lung cancer ECSIT involvement in TLR signaling affects cell proliferation and survival making it a protein of interest in cancer research. ECSIT's role in these conditions can involve interactions with mitochondrial proteins and signaling molecules like TRAF6 further illustrating its impact on human health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46853932187817,"sku":"ab21288","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab21288","provider":"Iright","version":"1.0","type":"link"}